Findings

What do systematic reviews say?

32 questions · 32 findings · 2 reviews · Gynaecology and Fertility

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No studies found 4 · 12.5%GRADE not reported 2 · 6.3%Very low 11 · 34.4%Low 14 · 43.8%Moderate 1 · 3.1%High 0 · 0%

Saline vs carbon dioxide

Tolerability of the procedure · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1705 participants
Low

Saline vs carbon dioxide

Adverse events and complications · women undergoing outpatient hysteroscopy

Saline probably leads to lower adverse events and complications compared with carbon dioxide (moderate certainty).

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
Peto OR 0.53 [0.32, 0.86]
6 studies · 1076 participants
Moderate

Saline vs carbon dioxide

Quality of hysteroscopic view · women undergoing outpatient hysteroscopy

Saline may leads to lower quality of hysteroscopic view compared with carbon dioxide (low certainty).

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
Peto OR 0.51 [0.32, 0.82]
5 studies · 1082 participants
Low

Saline vs carbon dioxide

Duration of the procedureassessed in seconds · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 4 participants
GRADE not reported

Warm saline vs room temperature saline

Tolerability of the procedure · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 241 participants
Low

Warm saline vs room temperature saline

Adverse events and complications · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
GRADE not reported

Warm saline vs room temperature saline

Quality of hysteroscopic view · women undergoing outpatient hysteroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Warm saline vs room temperature saline

Duration of the procedureassessed in seconds · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 141 participants
Low

Local anaesthetic vs placebo or no treatment

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1496 participants
Low

Oral NSAIDs vs placebo or no treatment

Non pelvic pain · women undergoing outpatient hysteroscopy

It is very uncertain whether oral NSAID changes non pelvic pain compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
OR 2.93 [0.12, 72.99]
1 study · 181 participants
Very low

Oral NSAIDs vs placebo or no treatment

Allergic reaction · women undergoing outpatient hysteroscopy

It is very uncertain whether oral NSAID changes allergic reaction compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
OR 2.93 [0.12, 72.99]
1 study · 181 participants
Very low

Opioids vs placebo or no treatment

Pain score during procedure: oral opioid · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 140 participants
Low

Opioids vs placebo or no treatment

Pain score during procedure: sublingual opioid · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 164 participants
Low

Opioids vs placebo or no treatment

Pain score within 30 min of procedure oral opioid · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 140 participants
Low

Opioids vs placebo or no treatment

Pain score more than 30 min after procedure oral opioid · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 140 participants
Very low

Opioids vs placebo or no treatment

Nausea and vomiting sublingual opioid · women undergoing outpatient hysteroscopy

Opioid may leads to higher nausea and vomiting sublingual opioid compared with placebo or no treatment (low certainty).

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
OR 107.55 [6.44, 1796.46]
1 study · 164 participants
Low

Intracervical vs combined intracervical and paracervical anaesthesia

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 84 participants
Very low

Intracervical vs combined intracervical and paracervical anaesthesia

Pain score within 30 min of procedure · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 84 participants
Very low

Intracervical vs combined intracervical and paracervical anaesthesia

Pain score more than 30 min after procedure · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 84 participants
Very low

Local anaesthetic vs placebo or no treatment

Pain score within 30 min of procedure · women undergoing outpatient hysteroscopy

1 finding from 1 review

Pain relief for outpatient hysteroscopy 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 545 participants
Low