Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Breast Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%

NSAIDs vs other analgesics

Other side effects of NSAID use · women undergoing breast surgery

It is very uncertain whether NSAID changes other side effects of NSAID use compared with other analgesic (very low certainty).

1 finding from 1 review

Perioperative systemic nonsteroidal anti‐inflammatory drugs (NSAIDs) in women undergoing breast surgery 2021 · Cochrane Headline outcomes only
RR 0.11 [0.01, 1.8]
1 study · 48 participants
Very low

NSAIDs vs placebo

Other side effects of NSAID use · women undergoing breast surgery

NSAID showed no clear difference in other side effects of NSAID use compared with placebo (low certainty).

1 finding from 1 review

Perioperative systemic nonsteroidal anti‐inflammatory drugs (NSAIDs) in women undergoing breast surgery 2021 · Cochrane Headline outcomes only
RR 1.12 [0.44, 2.86]
2 studies · 251 participants
Low

NSAIDs vs other analgesics

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · women undergoing breast surgery

NSAID probably leads to lower incidence rate or severity of postoperative nausea, vomiting, or both compared with other analgesic (moderate certainty).

1 finding from 1 review

Perioperative systemic nonsteroidal anti‐inflammatory drugs (NSAIDs) in women undergoing breast surgery 2021 · Cochrane Headline outcomes only
RR 0.18 [0.06, 0.57]
3 studies · 128 participants
Moderate

NSAIDs vs other analgesics

Bleeding from any location within 90 days · women undergoing breast surgery

It is very uncertain whether NSAID changes bleeding from any location within 90 days compared with other analgesic (very low certainty).

1 finding from 1 review

Perioperative systemic nonsteroidal anti‐inflammatory drugs (NSAIDs) in women undergoing breast surgery 2021 · Cochrane Headline outcomes only
RR 0.33 [0.01, 7.99]
1 study · 100 participants
Very low

NSAIDs vs other analgesics

Opioid use within 24 (± 12) hours of surgery · women undergoing breast surgery

1 finding from 1 review

Perioperative systemic nonsteroidal anti‐inflammatory drugs (NSAIDs) in women undergoing breast surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 178 participants
Low

NSAIDs vs other analgesics

Incidence of breast hematoma · women undergoing breast surgery

It is very uncertain whether NSAID changes incidence of breast hematoma within 90 days of breast surgery compared with other analgesic (very low certainty).

1 finding from 1 review

Perioperative systemic nonsteroidal anti‐inflammatory drugs (NSAIDs) in women undergoing breast surgery 2021 · Cochrane Headline outcomes only
RR 0.33 [0.01, 7.99]
1 study · 100 participants
Very low

NSAIDs vs other analgesics

Pain intensity 24 (± 12) hours following surgery · women undergoing breast surgery

1 finding from 1 review

Perioperative systemic nonsteroidal anti‐inflammatory drugs (NSAIDs) in women undergoing breast surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 200 participants
Low