Periodontal parameters (all measures pooled) in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)
Pooling all periodontal measures, oral cancer patients had worse periodontal status than controls (SMD 0.95, 95% CI 0.41-1.49; very high heterogeneity, I2=96.8%); ungraded. Note this pools clinically different measures.
1 finding from 1 review
Probing pocket depth · Adults in case-control studies (oral cancer patients vs healthy controls)
Periodontal pocket depth did not differ significantly between oral cancer patients and controls (SMD 1.64, 95% CI -0.20 to 3.47; very high heterogeneity); ungraded.
1 finding from 1 review
Alveolar bone loss · Adults in case-control studies (oral cancer patients vs healthy controls)
Alveolar bone loss did not differ significantly between oral cancer patients and controls (SMD 0.18, 95% CI -2.34 to 2.69; extreme heterogeneity); ungraded.
1 finding from 1 review
Dental caries · Adults in case-control studies (oral cancer patients vs healthy controls)
The DMFT index was significantly higher in oral cancer patients than controls (SMD 0.65, 95% CI 0.12-1.18); ungraded.
1 finding from 1 review
Mean number of missing teeth in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)
The mean number of missing teeth did not differ significantly between oral cancer patients and controls (SMD 0.59, 95% CI -0.04 to 1.22); ungraded.
1 finding from 1 review
Periodontitis (clinical attachment loss) · Adults in case-control studies (oral cancer patients vs healthy controls)
Clinical attachment loss was significantly greater in oral cancer patients than controls (SMD 1.94, 95% CI 0.22-3.66), though heterogeneity was very high (I2=96.7%); ungraded.
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies of oral cancer; people assessed for periodontitis
Periodontitis is associated with roughly a threefold higher odds of oral cancer (pooled OR 2.94, 95% CI 2.13-4.07; low certainty of evidence), though heterogeneity is moderate (I2=52.4%).
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
The number of missing teeth (per tooth) was not significantly associated with oral cancer (OR 0.96, 95% CI 0.92-1.01); ungraded.
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
Pooling across all missing-teeth measures, the overall association with oral cancer was not statistically significant (OR 1.20, 95% CI 0.97-1.48; high heterogeneity, I2=82.8%); ungraded.
1 finding from 1 review
Oral cancer risk · People with and without more than 15 missing teeth
More than 15 missing teeth was associated with higher odds of oral cancer.
1 finding from 1 review
OR 1.91 [1.01, 3.62]
5 studies
GRADE not reported
Intervention not reported
Oral cancer (OC)
The intervention led to higher oral cancer (OC); GRADE not reported.
1 finding from 1 review
OR 2.63 [1.92, 3.62]
7 studies
GRADE not reported
Oral mucosal moisture · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
One small study found that chewing hard (but not soft) gum increased oral mucosal moisture.
1 finding from 1 review