Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 3 reviews

No studies found 5 · 20.8%GRADE not reported 0 · 0%Very low 3 · 12.5%Low 11 · 45.8%Moderate 5 · 20.8%High 0 · 0%

Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy

Presence of intrauterine adhesions at second‐look hysteroscopy (6‐12 weeks) · women treated by operative hysteroscopy for uterine pathology associated with subfertility or adverse pregnancy outcome

Any anti‐adhesion therapy may leads to lower presence of intrauterine adhesions at second‐look hysteroscopy… compared with placebo or no treatment following operative hysteroscopy (low certainty).

1 finding from 1 review

Operative hysteroscopy vs control

Clinical pregnancya Ultrasound 12 months · women with submucous fibroids and otherwise unexplained subfertility

It is very uncertain whether operative hysteroscopy changes clinical pregnancya Ultrasound 12 months compared with control (very low certainty).

1 finding from 1 review

Operative hysteroscopy vs control

Adverse events: miscarriaged Ultrasound 12 months · women with submucous fibroids and otherwise unexplained subfertility

It is very uncertain whether operative hysteroscopy changes adverse events: miscarriaged Ultrasound 12 months compared with control (very low certainty).

1 finding from 1 review

Operative hysteroscopy vs control

Clinical pregnancya Ultrasound 4 intrauterine insemination cycles · subfertile women with endometrial polyps diagnosed by ultrasonography prior to treatment with gonadotropin and intrauterine insemination

Operative hysteroscopy may leads to higher clinical pregnancya Ultrasound 4 intrauterine insemination cycles compared with control (low certainty).

1 finding from 1 review

Any anti‐adhesion therapy vs anti‐adhesion therapy B following operative hysteroscopy

Presence of intrauterine adhesions at second‐look hysteroscopy (6‐12 weeks) · women treated by operative hysteroscopy for uterine pathology

Any anti‐adhesion therapy A may leads to lower presence of intrauterine adhesions at second‐look hysteroscopy (6‐12… compared with anti‐adhesion therapy B following operative hysteroscopy (low certainty).

1 finding from 1 review

Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy

Live birth · women treated by operative hysteroscopy for uterine pathology associated with subfertility or adverse pregnancy outcome

It is very uncertain whether any anti‐adhesion therapy changes live birth a compared with placebo or no treatment following operative hysteroscopy (very low certainty).

1 finding from 1 review

Any anti‐adhesion therapy vs anti‐adhesion therapy B following operative hysteroscopy

Live birth · women treated by operative hysteroscopy for uterine pathology

Any anti‐adhesion therapy A showed no clear difference in live birth a compared with anti‐adhesion therapy B following operative hysteroscopy (low certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Specific intraoperative complications ‐ Cervical laceration/tear · Pre and post menopausal women

Misoprostol probably leads to lower specific intraoperative complications ‐ Cervical laceration/tear compared with placebo or no treatment before operative hysteroscopy (moderate certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Specific intraoperative complications ‐ False track · Pre and post menopausal women

Misoprostol probably leads to lower specific intraoperative complications ‐ False track compared with placebo or no treatment before operative hysteroscopy (moderate certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Specific intraoperative complications ‐ Uterine perforation · Pre and post menopausal women

Misoprostol showed no clear difference in specific intraoperative complications ‐ Uterine perforation compared with placebo or no treatment before operative hysteroscopy (low certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Specific intraoperative complications ‐ Uterine bleeding · Pre and post menopausal women

Misoprostol showed no clear difference in specific intraoperative complications ‐ Uterine bleeding compared with placebo or no treatment before operative hysteroscopy (low certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Ease of dilatation: need for mechanical dilatation · Pre and post menopausal women

Misoprostol probably leads to lower ease of dilatation: need for mechanical dilatation compared with placebo or no treatment before operative hysteroscopy (moderate certainty).

1 finding from 1 review