Change in probing pocket depth (PPD) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in probing depth (PD) (mm) compared with OFD (open flap debridement) alone (very low certainty).
1 finding from 1 review
Tooth survival · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review
Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in radiographic bone defect filling (RBF) (%) compared with OFD (open flap debridement) alone (very low certainty).
1 finding from 1 review
Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
The review found no eligible studies for this question.
1 finding from 1 review
Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in clinical attachment level (CAL) (mm) compared with OFD (open flap debridement) alone (very low certainty).
1 finding from 1 review
Pocket closure (complete pocket closure) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review
Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
Autologous platelet concentrates (APC) + open flap debridement (OFD)… led to higher change in radiographic bone defect filling (RBF) (%) compared with OFD + BG (open flap debridement + bone graft); GRADE not reported.
3 findings from 1 review
MD 9.99 [6.44, 13.55]
6 studies · 282 participants
GRADE not reported
MD 4.76 [1.27, 8.25]
6 studies · 162 participants
GRADE not reported
MD 8.10 [5.26, 10.94]
11 studies · 420 participants
Very low
Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD)… changes change in clinical attachment level (CAL) (mm) compared with OFD + BG (open flap debridement + bone graft) (very low certainty).
3 findings from 1 review
MD 0.72 [0.43, 1.00]
17 studies · 569 participants
Very low
MD 0.47 [0.11, 0.84]
11 studies · 272 participants
GRADE not reported
MD 0.84 [0.62, 1.06]
6 studies · 192 participants
GRADE not reported
Change in probing pocket depth (PPD) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD)… changes change in probing depth (PD) (mm) compared with OFD + BG (open flap debridement + bone graft) (very low certainty).
3 findings from 1 review
MD 0.54 [0.33, 0.75]
17 studies · 569 participants
Very low
MD 0.62 [0.30, 0.94]
11 studies · 272 participants
GRADE not reported
MD 0.50 [0.31, 0.69]
10 studies · 381 participants
GRADE not reported
Pocket closure (complete pocket closure) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review
Tooth survival · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review
Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
The review found no eligible studies for this question.
1 finding from 1 review
Sites failing to gain 2 mm attachment (proportion) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…
Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to lower sites failing to gain 2 mm attachment (proportion) compared with open flap debridement (access flap surgery); GRADE not reported.
1 finding from 1 review
RR 0.54 [0.31, 0.96]
6 studies
GRADE not reported
Aesthetics · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…
The review found no eligible studies for this question.
1 finding from 1 review
Change in gingival recession (REC) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…
Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher change in gingival recession compared with open flap debridement (access flap surgery); GRADE not reported.
1 finding from 1 review
MD 0.26 [0.08, 0.43]
9 studies
GRADE not reported
Treatment / surgical procedure time · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…
Guided tissue regeneration (GTR) with barrier membrane (resorbable… showed no clear difference in treatment / surgical procedure time compared with open flap debridement (access flap surgery); GRADE not reported.
1 finding from 1 review
MD 23.9
1 study
GRADE not reported
Attachment change · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…
Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher change in clinical attachment level (attachment gain) compared with open flap debridement (access flap surgery); GRADE not reported.
1 finding from 1 review
MD 1.22 [0.80, 1.64]
16 studies
GRADE not reported
Hard tissue probing at surgical re-entry (bone gain) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…
Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher hard tissue probing at surgical re-entry (bone gain) compared with open flap debridement (access flap surgery); GRADE not reported.
1 finding from 1 review
MD 1.39 [1.08, 1.71]
3 studies
GRADE not reported
Cost/benefit (treatment time plus estimated material costs) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…
The review found no eligible studies for this question.
1 finding from 1 review
Hard tissue probing at surgical re-entry (bone gain) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…
Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher hard tissue probing at surgical re-entry (bone gain) compared with open flap debridement (access flap surgery); GRADE not reported.
1 finding from 1 review
MD 3.37 [3.14, 3.61]
1 study
GRADE not reported