What do systematic reviews say?

Primary school-based interventions (one or more of: school health policy, oral health education, healthy school environment, access to oral health services, community involvement) vs usual practice

School-based interventions may reduce the prevalence of dental caries (RR 0.70, favouring intervention), but the certainty of evidence is very low.

• Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomes

  Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer) · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean)
  RR 0.70 [0.53, 0.94]
  4 studies · 2968 participants
  Very low
• Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomes

  <2 years · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · Intervention duration <2 years
  RR 0.95 [0.75, 1.21]
  2 studies
  GRADE not reported
• Effectiveness of primary school-based interventions in improving oral health of children in low- and middle-income… 2022 All outcomes

  >=2 years · Primary schools in low- and middle-income countries (Southeast Asia, Africa, the Americas, Europe, eastern Mediterranean) · Intervention duration >=2 years
  RR 0.58 [0.40, 0.84]
  2 studies
  GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

The review found no eligible studies for this question.

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  No data were provided in any of the included trials on time to intervention.
  Studies not reported
  No studies found

An intervention delivered at one time point vs The same intervention delivered at a different time point

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes

  < 3 months; ≤ 6 months; > 6 months
  Discussion / Methods: no trials addressed optimal timing; the planned timing subgroup analyses (< 3 months, ≤ 6 months, > 6 months) could not be undertaken.
  0 studies
  No studies found

One active intervention (surgical, medical, or psychological) vs A different active intervention (direct head-to-head comparison)

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  Discussion: 'There is also a lack of trials directly comparing these methods ...'. No eligible RCT directly comparing different active interventions.
  0 studies
  No studies found

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Primary school-based behavioural intervention (both oral hygiene and… showed no clear difference in plaque indices (permanent and deciduous teeth) compared with no intervention or delayed intervention (non-intervention control;… (low certainty).

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes

  3 to 15 months
  SoF (Plaque indices, follow-up 3 to 15 months): 'All 3 RCTs showed a reduction in plaque in the intervention group compared to control group'; 827 participants (3 RCTs); GRADE low; comment 'Data not suitable for…
  3 studies · 827 participants
  Low

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes

  15 months
  PF 0.65 [0.12, 1.18]
  1 study · 60 participants
  Low

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
  Worthington 2001 reported changes in oral health knowledge and skills: improvement was apparent in both intervention and control groups at the 4-month follow-up (phase one) but greater in the intervention group (34%…
  1 study
  GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
  Worthington 2001 found no change in reported dental visits over the course of the programmes, with 97% of children at baseline reporting visiting the dentist every 2 years.
  1 study
  GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

The review found no eligible studies for this question.

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
  No other behavioural outcomes (e.g. objective toothbrush tracking or food-wrapper collection) were measured by the four included studies.
  0 studies
  No studies found

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

The review found no eligible studies for this question.

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
  No study reported any adverse events.
  0 studies
  No studies found

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes

  2 years
  PF 0.49
  1 study
  GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
  Worthington 2001: few children had problems identifying foods containing sugar; only 15% of intervention and 19% of control participants reported routinely consuming sugary snacks on arriving home from school; snacking…
  1 study
  GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
  Worthington 2001 reported children's brushing frequency: almost all children (99%) at baseline reported twice daily brushing, and this level was maintained across all groups throughout the intervention (in baseline…
  1 study
  GRADE not reported

Any intervention for KCOT (e.g. enucleation), alone or combined with an adjunctive therapy (ostectomy, cryotherapy, or Carnoy's solution) vs A different intervention (e.g. enucleation versus marsupialisation), or the same surgical intervention without the adjunctive therapy

The review found no eligible studies for this question.

• Interventions for the treatment of keratocystic odontogenic tumours 2015 · Cochrane All outcomes
  No randomised controlled trials that met the inclusion criteria were identified. In view of the fact that no studies were identified, no data were available for analysis.
  0 studies
  No studies found

ARP with xenograft (bone graft) vs Extraction alone

• Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development 2021 · Cochrane All outcomes

  7 months
  Peri-implant marginal bone level changes obtained after 7 months (Barone 2012); no statistically significant differences between the two groups (Analysis 1.5)
  1 study
  GRADE not reported

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

The review found no eligible studies for this question.

• Oral health educational interventions for nursing home staff and residents 2016 · Cochrane All outcomes
  None of the included studies assessed adverse effects of the intervention.
  0 studies
  No studies found

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

The review found no eligible studies for this question.

• Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sinus lift with bone graft (granular Bio-Oss) vs Sinus lift without bone graft (Inion resorbable rigid barrier maintaining space / no bone)

Sinus lift with bone graft (granular Bio-Oss) showed no clear difference in bone gain compared with sinus lift without bone graft (Inion resorbable rigid barrier…; GRADE not reported.

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  18 months after augmentation
  MD -0.10 [-0.47, 0.27]
  1 study · 39 participants
  GRADE not reported
• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  6 months after augmentation
  MD 0.26 [-0.91, 1.43]
  1 study · 9 participants
  GRADE not reported
• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  30 months after augmentation
  MD 0.10 [-1.04, 1.24]
  1 study · 39 participants
  GRADE not reported

One-to-one dietary intervention aimed at preventing tooth erosion (e.g., reducing consumption of acidic/carbonated drinks) vs No dietary advice, or different dietary advice

The review found no eligible studies for this question.

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes
  There were no studies concerned with dietary change aimed at preventing tooth erosion.
  0 studies
  No studies found

Platelet-rich fibrin after bone surgery vs Bone surgery alone

It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity, absence of infection, and no… compared with bone surgery alone (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  1 year
  RR 1.60 [1.04, 2.46]
  1 study · 47 participants
  Very low