What do systematic reviews say?

Intraperitoneal vs oral calcitriol

Intraperitoneal showed no clear difference in abnormal bone histology Bone biopsy compared with oral calcitriol (low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 1.06 [0.7, 1.61]
  1 study · 33 participants
  Low

Intraperitoneal vs oral calcitriol

Intraperitoneal showed no clear difference in adynamic bone disease Bone histology compared with oral calcitriol (low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 1.49 [0.59, 3.74]
  1 study · 33 participants
  Low

Intraperitoneal vs oral calcitriol

Intraperitoneal showed no clear difference in osteitis fibrosa Bone histology compared with oral calcitriol (low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 0.35 [0.08, 1.51]
  1 study · 33 participants
  Low

Astragalus and co‐interventions vs co‐intervention alone

• Astragalus (a traditional Chinese medicine) for treating chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Astragalus and co‐interventions vs co‐intervention alone

• Astragalus (a traditional Chinese medicine) for treating chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Astragalus and co‐interventions vs co‐intervention alone

• Astragalus (a traditional Chinese medicine) for treating chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 306 participants
  Low

Astragalus and co‐interventions vs co‐intervention alone

• Astragalus (a traditional Chinese medicine) for treating chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 841 participants
  Low

Astragalus and co‐interventions vs co‐intervention alone

• Astragalus (a traditional Chinese medicine) for treating chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 706 participants
  Low

Astragalus and co‐interventions vs co‐intervention alone

• Astragalus (a traditional Chinese medicine) for treating chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 588 participants
  Low

Astragalus and co‐interventions vs co‐intervention alone

• Astragalus (a traditional Chinese medicine) for treating chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 222 participants
  Moderate

Intraperitoneal vs oral calcitriol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Low

Intraperitoneal vs oral calcitriol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Low

Intraperitoneal vs oral calcitriol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Low

Intraperitoneal vs oral calcitriol

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 21 participants
  Low

Vitamin D vs placebo or no treatment

• Interventions for preventing bone disease in kidney transplant recipients 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Bisphosphonates vs placebo or no treatment

Bisphosphonate may leads to lower bone pain compared with placebo or no treatment (low certainty).

• Interventions for preventing bone disease in kidney transplant recipients 2019 · Cochrane Headline outcomes only
  RR 0.2 [0.04, 0.93]
  3 studies · 153 participants
  Low

Calcitriol vs ergocalciferol

It is very uncertain whether calcitriol changes improved bone histology compared with ergocalciferol (very low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 1.53 [0.77, 3.06]
  1 study · 15 participants
  Very low

Calcium carbonate vs aluminium hydroxide

It is very uncertain whether calcium carbonate changes abnormal bone biopsy Bone histology compared with aluminium hydroxide (very low certainty).

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  RR 0.35 [0.13, 0.95]
  1 study · 17 participants
  Very low

Calcium carbonate vs aluminium hydroxide

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Summary of findings: Sevelamer vs calcium carbonate

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low