Cochrane · systematic review · CD005015
Interventions for preventing bone disease in kidney transplant recipients
Palmer, SC, Chung, EYM, McGregor, DO, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 10 · 76.9%Low 3 · 23.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Bisphosphonate compared to placebo or no treatment for preventing bone disease in kidney transplant recipients
Population: preventing bone disease in kidney transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fracture Bisphosphonate vs placebo or no treatment | RR 0.62 [0.38, 1.01] | 13 studies · 765 participants | Low |
Acute graft rejection Bisphosphonate vs placebo or no treatment | RR 0.7 [0.55, 0.89] | 7 studies · 470 participants | Low |
Death (all causes) Bisphosphonate vs placebo or no treatment | RR 0.98 [0.34, 2.8] | 10 studies · 597 participants | Very low |
Cardiovascular death Bisphosphonate vs placebo or no treatment | RR 0.33 [0.01, 7.58] | 3 studies · 150 participants | Very low |
Bone pain Bisphosphonate vs placebo or no treatment | RR 0.2 [0.04, 0.93] | 3 studies · 153 participants | Low |
Spinal deformity Bisphosphonate vs placebo or no treatment | RR 0.58 [0.26, 1.31] | 1 study · 72 participants | Very low |
Hypocalcaemia Bisphosphonate vs placebo or no treatment | RR 5.59 [1, 31.06] | 4 studies · 207 participants | Very low |
Vitamin D compared to placebo or no treatment for preventing bone disease in kidney transplant recipients
Population: preventing bone disease in kidney transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fracture Vitamin D vs placebo or no treatment | RR 0.96 [0.1, 8.94] | 5 studies · 299 participants | Very low |
Acute graft rejection Vitamin D vs placebo or no treatment | RR 0.98 [0.52, 1.86] | 5 studies · 385 participants | Very low |
Death (all causes) Vitamin D vs placebo or no treatment | RR 0.49 [0.03, 9.22] | 3 studies · 232 participants | Very low |
Cardiovascular death Vitamin D vs placebo or no treatment | RR 0.57 [0.04, 7.57] | 3 studies · 232 participants | Very low |
Bone pain Vitamin D vs placebo or no treatment | no estimate extracted | 1 study · 40 participants | Very low |
Graft loss Vitamin D vs placebo or no treatment | RR 0.11 [0.01, 2.01] | 3 studies · 220 participants | Very low |