Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 2 reviews · Pregnancy and Childbirth

No studies found 4 · 21.1%GRADE not reported 0 · 0%Very low 3 · 15.8%Low 9 · 47.4%Moderate 3 · 15.8%High 0 · 0%

Ondansetron vs promethazine

Length of hospital stay · Pregnant women with hyperemesis gravidarum

It is very uncertain whether ondansetron changes days of hospital admission compared with promethazine (very low certainty).

1 finding from 1 review

Ondansetron vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Quality of life outcomes 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Metoclopramide vs ondansetron

Intervention side effects: unable to sleep · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: unable to sleep compared with ondansetron (low certainty).

1 finding from 1 review

Metoclopramide vs ondansetron

Adverse effects: dry mouth · Pregnant women with hyperemesis gravidarum

Metoclopramide probably leads to higher intervention side effects: dry mouth compared with ondansetron (moderate certainty).

1 finding from 1 review

Metoclopramide vs ondansetron

Frequency of adverse effects ‐ dizziness ( · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: felt dizzy compared with ondansetron (low certainty).

1 finding from 1 review

Metoclopramide vs ondansetron

Severity, reduction or cessation in nausea/vomiting 2.Days of hospital admission 3. Pregnancy complications 4. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review