Findings

What do systematic reviews say?

10 questions · 10 findings · 2 reviews · Neonatal

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No studies found 7 · 70%GRADE not reported 0 · 0%Very low 3 · 30%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Non‐pharmacological treatment vs placebo

Primary outcomes · infants at risk for, or having early symptoms consistent with, opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological care for opioid withdrawal in newborns 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Non‐pharmacological treatment vs placebo

– Modifying environmental stimulation · infants at risk for, or having early symptoms consistent with, opioid withdrawal

1 finding from 1 review

Non‐pharmacological care for opioid withdrawal in newborns 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Non‐pharmacological treatment vs placebo

– Feeding practices · infants at risk for, or having early symptoms consistent with, opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological care for opioid withdrawal in newborns 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Non‐pharmacological treatment vs placebo

– Support of the mother‐infant dyad · infants at risk for, or having early symptoms consistent with, opioid withdrawal

1 finding from 1 review

Non‐pharmacological care for opioid withdrawal in newborns 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Non‐pharmacological treatment vs placebo

Admission to NICU (primary outcome)№ of participants: 204(1 RCT) · infants at risk for, or having early symptoms consistent with, opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Non‐pharmacological care for opioid withdrawal in newborns 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NMDA receptor antagonists vs no treatment, placebo, oral sweet solution, or non‐pharmacological intervention

NFCS pain score during the procedure№ of infants: 112(2 RCTs) Score · procedural pain in neonates

1 finding from 1 review

Non‐opioid analgesics for procedural pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

NMDA receptor antagonists vs no treatment, placebo, oral sweet solution, or non‐pharmacological intervention

Pain score assessed up to 10 minutes after the procedure · procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Non‐opioid analgesics for procedural pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NMDA receptor antagonists vs no treatment, placebo, oral sweet solution, or non‐pharmacological intervention

Episodes of bradycardia · procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Non‐opioid analgesics for procedural pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NMDA receptor antagonists vs no treatment, placebo, oral sweet solution, or non‐pharmacological intervention

Episodes of apnea · procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Non‐opioid analgesics for procedural pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NMDA receptor antagonists vs no treatment, placebo, oral sweet solution, or non‐pharmacological intervention

Hypotension requiring medical therapy (vasopressors or fluid boluses), occurring during the procedure · procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Non‐opioid analgesics for procedural pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found