Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

73 questions · 82 findings · 7 reviews

No studies found 40 · 48.8%GRADE not reported 5 · 6.1%Very low 20 · 24.4%Low 14 · 17.1%Moderate 3 · 3.7%High 0 · 0%

Negative pressure wound therapy vs standard dressing

Wound dehiscence · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in dehiscence (proportion of participants in each group with wound… compared with standard dressing (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Time to complete healing · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether topical negative pressure wound therapy changes time to wound healing (days) compared with conventional open wound healing (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether topical negative pressure wound therapy changes proportion of wounds healed at 30 days compared with conventional open wound healing (very low certainty).

3 findings from 1 review

Negative pressure wound therapy vs standard dressing

Mortality (proportion of participants dying in each group at · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in mortality (proportion of participants dying in each group at compared with standard dressing (low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Surgical site infection · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy probably leads to lower surgical site infection (proportion of participants in each group… compared with standard dressing (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Seroma (proportion of participants in each group with seroma; · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in seroma (proportion of participants in each group with seroma; compared with standard dressing (low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Haematoma (proportion of participants in each group with haematoma; · adult patients with surgical wounds healing by primary closure

It is very uncertain whether negative pressure wound therapy changes haematoma (proportion of participants in each group with haematoma; compared with standard dressing (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Skin blisters (proportion of participants in each group with at least one skin blister; · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy may leads to higher skin blisters (proportion of participants in each group with at… compared with standard dressing (low certainty).

1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

The review found no eligible studies for this question.

1 finding from 1 review

Low‐pressure vs high‐pressure NPWT

Number of wounds closed or covered with surgery · treating foot wounds in people with diabetes mellitus

It is very uncertain whether low‐pressure changes number of wounds closed or covered with surgery compared with high‐pressure NPWT (very low certainty).

1 finding from 1 review