Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 29 findings · 5 reviews · Headline outcomes only

No studies found 8 · 27.6%GRADE not reported 0 · 0%Very low 17 · 58.6%Low 4 · 13.8%Moderate 0 · 0%High 0 · 0%

Laser therapy plus other treatment vs other treatment

Scar severity: Nd:YAG laser plus Diprospan plus 5‐FU versus Diprospan plus 5‐FU ‐ patient self‐assessment of scar improvement of 50% or higher ‐ keloid scars ‐ · participants with hypertrophic and keloid scars

It is very uncertain whether laser therapy plus other treatment changes scar severity: Nd:YAG laser plus Diprospan plus 5‐FU versus… compared with other treatment (very low certainty).

1 finding from 1 review

Nd:YAG laser vs no treatment/sham

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

It is very uncertain whether 1064‐nm Nd:YAG laser changes adverse events (collected over the course of the studies; they are… compared with no treatment or sham treatment (very low certainty).

1 finding from 1 review