Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

No studies found 1 · 25%GRADE not reported 3 · 75%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia

1 finding from 1 review

Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
3 months
SoF 3, Clinical resolution (not completely resolved) at 3 months: '1 study evaluated systemic treatment and 1 evaluated topical treatment. Neither found benefit for NSAIDs.' No GRADE. Effects text: celecoxib…
2 studies
GRADE not reported

Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia

1 finding from 1 review

Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
SoF 3 (NSAIDs vs placebo), Cancer development: SoF cell 'Not measured'. Effects text: cancer development was among outcomes in Papadimitrakopoulou 2008 (celecoxib) but did not occur in either arm, probably because of…
1 study
GRADE not reported

Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia

1 finding from 1 review

Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
over 3 months
SoF 3, Safety of the intervention over 3 months: systemic celecoxib (1 study) - 32 intervention participants reported 56 adverse effects, 20 placebo participants reported 20; 4 grade 3 events; 2 discontinued. Ketorolac…
2 studies
GRADE not reported

Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
SoF 3, Histological changes: 'Not measured'. Effects text: 'Histological changes were not among the outcomes in the studies testing NSAIDs.'
0 studies
No studies found