Findings

What do systematic reviews say?

25 questions · 25 findings · 2 reviews · Anaesthesia

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No studies found 5 · 20%GRADE not reported 0 · 0%Very low 4 · 16%Low 11 · 44%Moderate 2 · 8%High 3 · 12%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs control or placebo medications · Acute postoperative pain at 48 hours (Score 0 to 10, VAS or NRS Scale)
  Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 149 participants
  Very low
Direct match · question page
- Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs control or placebo medications · Analgesic Success
  Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low
Direct match · question page
- Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs control or placebo medications · Acute postoperative pain at 12 hours (Score 0 to 10, VAS or NRS Scale)
  Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 742 participants
  High
Direct match · question page
- Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs control or placebo medications · Acute postoperative pain at 24 hours (Score 0 to 10, VAS or NRS Scale)
  Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 742 participants
  High
Direct match · question page
- Nonsteroidal anti‐inflammatory drugs (NSAIDs) vs control or placebo medications · Acute postoperative pain 0 to 6 hours (Score 0 to 10, VAS or NRS Scale)
  Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 742 participants
  High

NSAIDs vs control or placebo medications

Acute postoperative pain 0 to 6 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 742 participants
High

NSAIDs vs control or placebo medications

Length of hospital stay · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Nonsteroidal anti‐inflammatory drugs (NSAIDs) showed no clear difference in adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 345 participants
Low

NSAIDs vs control or placebo medications

Acute postoperative pain at 12 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 742 participants
High

NSAIDs vs control or placebo medications

Acute postoperative pain at 24 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 742 participants
High

NSAIDs vs control or placebo medications

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 149 participants
Very low

NSAIDs vs control or placebo medications

Analgesia requirements · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 265 participants
Low

NSAIDs vs control or placebo medications

Analgesic Success · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

NSAIDs vs control or placebo medications

Adverse effects: 1. Sedation · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs control or placebo medications

Chronic Headache · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs control or placebo medications

Length of critical care stay (hours) · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Early acute postoperative pain (within 6 hours postoperatively using a validated pain scale: 0, no pain to 10, maximum pain) · adults undergoing surgery

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
36 studies · 2032 participants
Moderate

Intervention not reported

Nausea and vomiting (1‐6 hours postoperatively) · adults undergoing surgery

The intervention showed no clear difference in nausea and vomiting (1‐6 hours postoperatively) (low certainty).

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
RR 1.26 [0.49, 3.3]
1 study · 76 participants
Low

Intervention not reported

Nausea and vomiting (6‐48 hours postoperatively) · adults undergoing surgery

The intervention showed no clear difference in nausea and vomiting (6‐48 hours postoperatively) (low certainty).

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
RR 0.89 [0.65, 1.22]
8 studies · 456 participants
Low

Intervention not reported

Late acute postoperative pain (24‐48 hours postoperatively using a validated pain scale: 0, no pain to 10, maximum pain) · adults undergoing surgery

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
21 studies · 1441 participants
Low

Intervention not reported

24‐hour morphine consumption (mg) · adults undergoing surgery

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 1323 participants
Moderate

Intervention not reported

Time to first analgesic request (mean time in minutes) · adults undergoing surgery

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 410 participants
Very low

Intervention not reported

Adverse events · adults undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Nausea and vomiting (1‐6 hours postoperatively) · adults undergoing surgery

The intervention showed no clear difference in nausea and vomiting (1‐6 hours postoperatively) (low certainty).

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
RR 1 [0.34, 2.94]
2 studies · 100 participants
Low

Intervention not reported

Nausea and vomiting (6‐48 hours postoperatively) · adults undergoing surgery

The intervention showed no clear difference in nausea and vomiting (6‐48 hours postoperatively) (low certainty).

1 finding from 1 review

Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery 2021 · Cochrane Headline outcomes only
RR 0.85 [0.52, 1.38]
5 studies · 228 participants
Low