Findings

What do systematic reviews say?

20 questions · 20 findings · 3 reviews · Hypertension

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 16 · 80%Low 0 · 0%Moderate 2 · 10%High 2 · 10%

Combination therapy vs monotherapy

Total mortality · people with primary hypertension

It is very uncertain whether combination therapy changes total mortality compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 1.35 [0.08, 21.72]
3 studies · 568 participants
Very low

Combination with potassium‐sparing diuretics vs monotherapy

Withdrawals due to adverse events · people with primary hypertension

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 200 participants
Very low

Combination therapy vs monotherapy

Cardiovascular mortality · people with primary hypertension

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 568 participants
Very low

Combination therapy vs monotherapy

Cardiovascular events · people with primary hypertension

It is very uncertain whether combination therapy changes cardiovascular events compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.98 [0.22, 4.41]
3 studies · 568 participants
Very low

Combination therapy vs monotherapy

Serious adverse events · people with primary hypertension

It is very uncertain whether combination therapy changes serious adverse events compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.77 [0.31, 1.92]
3 studies · 568 participants
Very low

Combination therapy vs monotherapy

Withdrawals due to adverse events · people with primary hypertension

It is very uncertain whether combination therapy changes withdrawals due to adverse effects compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.85 [0.53, 1.35]
3 studies · 568 participants
Very low

Combination with potassium‐sparing diuretics vs monotherapy

Total mortality · people with primary hypertension

It is very uncertain whether combination with potassium‐sparing diuretics changes total mortality compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.24 [0.01, 5.87]
1 study · 200 participants
Very low

Combination with potassium‐sparing diuretics vs monotherapy

Cardiovascular mortality · people with primary hypertension

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 200 participants
Very low

Combination with potassium‐sparing diuretics vs monotherapy

Cardiovascular events · people with primary hypertension

It is very uncertain whether combination with potassium‐sparing diuretics changes cardiovascular events compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 1.45 [0.13, 15.71]
1 study · 200 participants
Very low

Combination with potassium‐sparing diuretics vs monotherapy

Serious adverse events · people with primary hypertension

It is very uncertain whether combination with potassium‐sparing diuretics changes serious adverse events compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.72 [0.1, 5.04]
1 study · 200 participants
Very low

Intervention not reported

Systolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 663 participants
Moderate

Intervention not reported

Diastolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 662 participants
Moderate

Intervention not reported

Systolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 7733 participants
High

Intervention not reported

Diastolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
51 studies · 8064 participants
High

Intervention not reported

Withdrawal due to adverse effects · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
20 studies · 3698 participants
Very low

Intervention not reported

Decrease in systolic blood pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 490 participants
Very low

Intervention not reported

Decrease in diastolic blood pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 490 participants
Very low

Intervention not reported

Decrease in heart rate · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 256 participants
Very low

Intervention not reported

Decrease in pulse pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 490 participants
Very low

Intervention not reported

Withdrawal due to adverse effect · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 117 participants
Very low