Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

20 questions · 20 findings · 3 reviews · All outcomes

No studies found 2 · 10%GRADE not reported 12 · 60%Very low 2 · 10%Low 4 · 20%Moderate 0 · 0%High 0 · 0%

3Mix (ciprofloxacin + metronidazole + minocycline) vs Ciprofloxacin + ornidazole + minocycline

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Plaque · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in plaque compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Change in probing pocket depth (PPD) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Change in probing pocket depth (worst sites) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth (worst sites) compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Soreness in the gums · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in soreness in the gums compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy vs 3Mix pulpectomy

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in clinical failure compared with 3Mix pulpectomy; GRADE not reported.

1 finding from 1 review

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy vs 3Mix pulpectomy

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in radiological failure compared with 3Mix pulpectomy; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Percentage of bleeding on probing (BOP) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

It is very uncertain whether mechanical debridement plus local antimicrobial (minocycline… changes bleeding on probing (ratios) compared with mechanical debridement alone (very low certainty).

1 finding from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Adverse events · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)
1 finding from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Probing pocket depth (PPD/PD) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in pocket depth (mm) compared with mechanical debridement alone (low certainty).

1 finding from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Clinical attachment level (CAL) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in clinical attachment level (mm) compared with mechanical debridement alone (low certainty).

1 finding from 1 review

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

1 finding from 1 review

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

1 finding from 1 review