Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Adverse events · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.
1 finding from 1 review
All three included trials (Matarazzo 2008; Silva 2011; Xajigeorgiou 2006) reported adverse events in both MTZ + SRP and AMOX + MTZ + SRP groups (nausea, vomiting, diarrhoea, headache, metallic taste, irritability, mild…
3 studies · 84 participants
GRADE not reported
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes probing pocket depth compared with SRP (very low certainty).
3 findings from 1 review
MD -1.11 [-2.84, 0.61]
2 studies · 47 participants
Very low
MD -0.59 [-0.95, -0.23]
4 studies · 94 participants
GRADE not reported
MD -0.10 [-0.37, 0.16]
4 studies · 108 participants
GRADE not reported
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes percentage of bleeding on probing (BOP) compared with SRP (very low certainty).
3 findings from 1 review
MD -6.90 [-22.10, 8.30]
1 study · 22 participants
Very low
MD -9.00 [-16.59, -1.40]
4 studies · 108 participants
GRADE not reported
MD -4.62 [-18.83, 9.58]
2 studies · 45 participants
GRADE not reported
Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes percentage of closed pockets compared with SRP (very low certainty).
3 findings from 1 review
MD -12.20 [-29.23, 4.83]
1 study · 22 participants
Very low
MD -7.00 [-23.57, 9.57]
1 study · 22 participants
GRADE not reported
MD -2.56 [-12.33, 7.22]
2 studies · 51 participants
GRADE not reported
Adverse events · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes adverse events compared with SRP (very low certainty).
1 finding from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.04 [-0.43, 0.50]
4 studies · 108 participants
GRADE not reported
MD -1.12 [-2.24, 0.00]
3 studies · 71 participants
Very low
MD -0.49 [-1.29, 0.31]
4 studies · 94 participants
GRADE not reported
Antimicrobial resistance · Adults with periodontitis (chronic and aggressive)
The review found no eligible studies for this question.
1 finding from 1 review
Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)
The review found no eligible studies for this question.
1 finding from 1 review
Duration of treatment (days) · Adults (>18 years) with established dry socket following permanent tooth extraction
Metronidazole (intrasocket) led to lower duration of treatment (days) compared with placebo; GRADE not reported.
1 finding from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.47 [-0.68, -0.26]
6 studies · 215 participants
GRADE not reported
MD -0.18 [-0.33, -0.04]
15 studies · 562 participants
GRADE not reported
MD -0.30 [-0.42, -0.18]
2 studies · 389 participants
Very low
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -2.05 [-2.98, -1.11]
13 studies · 460 participants
GRADE not reported
MD -5.32 [-12.02, 1.37]
5 studies · 172 participants
GRADE not reported
MD -8.06 [-14.26, -1.85]
2 studies · 389 participants
Very low
Probing pocket depth · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.47 [-0.90, -0.05]
2 studies · 389 participants
Very low
MD -0.21 [-0.41, -0.01]
13 studies · 501 participants
GRADE not reported
MD -0.04 [-0.35, 0.26]
6 studies · 215 participants
GRADE not reported
Adverse events · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.
1 finding from 1 review
Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower percentage of closed pockets compared with SRP; GRADE not reported.
3 findings from 1 review
MD -13.90 [-24.16, -3.64]
1 study · 44 participants
GRADE not reported
MD -16.20 [-25.87, -6.53]
1 study · 44 participants
Very low
MD -10.05 [-18.78, -1.32]
2 studies · 73 participants
GRADE not reported
Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)
The review found no eligible studies for this question.
1 finding from 1 review