Findings

What do systematic reviews say?

21 questions · 21 findings · 2 reviews · Pregnancy and Childbirth

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No studies found 3 · 14.3%GRADE not reported 0 · 0%Very low 4 · 19%Low 9 · 42.9%Moderate 5 · 23.8%High 0 · 0%

Metoclopramide vs ondansetron

Nausea severity · Pregnant women with hyperemesis gravidarum

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 83 participants
Very low

Metoclopramide vs ondansetron

Severity of vomiting · Pregnant women with hyperemesis gravidarum

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 83 participants
Very low

Metoclopramide vs ondansetron

Quality of life · Pregnant women with hyperemesis gravidarum

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 160 participants
Moderate

Metoclopramide vs ondansetron

Somnolence · Pregnant women with hyperemesis gravidarum

Metoclopramide probably leads to higher intervention side effects: felt drowsy compared with ondansetron (moderate certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 2.4 [1.23, 4.69]
1 study · 160 participants
Moderate

Metoclopramide vs ondansetron

Intervention side effects: unable to sleep · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: unable to sleep compared with ondansetron (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 1.29 [0.5, 3.28]
1 study · 160 participants
Low

Metoclopramide vs ondansetron

Adverse effects: dry mouth · Pregnant women with hyperemesis gravidarum

Metoclopramide probably leads to higher intervention side effects: dry mouth compared with ondansetron (moderate certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 2.38 [1.1, 5.11]
1 study · 160 participants
Moderate

Metoclopramide vs ondansetron

Frequency of adverse effects ‐ dizziness ( · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: felt dizzy compared with ondansetron (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 2.33 [0.94, 5.77]
1 study · 160 participants
Low

Metoclopramide vs ondansetron

Severity, reduction or cessation in nausea/vomiting 2.Days of hospital admission 3. Pregnancy complications 4. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metoclopramide vs promethazine

Quality of life · Pregnant women with hyperemesis gravidarum

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 149 participants
Low

Metoclopramide vs promethazine

Somnolence · Pregnant women with hyperemesis gravidarum

Metoclopramide probably leads to lower intervention side effects: drowsy compared with promethazine (moderate certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.7 [0.56, 0.87]
1 study · 143 participants
Moderate

Metoclopramide vs promethazine

Intervention side effects: unable to sleep · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: unable to sleep compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.78 [0.4, 1.53]
1 study · 143 participants
Low

Metoclopramide vs promethazine

Adverse effects: dry mouth · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: dry mouth compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.91 [0.62, 1.34]
1 study · 143 participants
Low

Metoclopramide vs promethazine

Frequency of adverse effects ‐ dizziness ( · Pregnant women with hyperemesis gravidarum

Metoclopramide probably leads to lower intervention side effects: felt dizzy compared with promethazine (moderate certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.48 [0.34, 0.69]
1 study · 143 participants
Moderate

Metoclopramide vs promethazine

Gastrointestinal side effects (diarrhoea) ‐ not reported · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: diarrhea compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 1.39 [0.32, 5.99]
1 study · 143 participants
Low

Metoclopramide vs promethazine

Adverse effects: headache · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: headache compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.81 [0.47, 1.38]
1 study · 143 participants
Low

Metoclopramide vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Days of hospital admission 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pharmacological oral galactagogues vs placebo or no treatment

Infant weight (where they were only receiving own mother's milk) at the end of the study (grams) ( · increasing breast milk production in mothers of non‐hospitalised term infants

1 finding from 1 review

Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non‐hospitalised… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Pharmacological oral galactagogues vs placebo or no treatment

Volume of breast milk at the latest time measured (mL) ‐ domperidone, metoclopramide, sulpiride ( · increasing breast milk production in mothers of non‐hospitalised term infants

1 finding from 1 review

Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non‐hospitalised… 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 151 participants
Low

Acupuncture vs metoclopramide

Reduction or cessation in nausea · Pregnant women with hyperemesis gravidarum

It is very uncertain whether acupuncture changes reduction or cessation in nausea compared with metoclopramide (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 1.4 [0.79, 2.49]
1 study · 81 participants
Very low

Acupuncture vs metoclopramide

Reduction or cessation in vomiting · Pregnant women with hyperemesis gravidarum

It is very uncertain whether acupuncture changes reduction or cessation in vomiting compared with metoclopramide (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 1.51 [0.92, 2.48]
1 study · 81 participants
Very low