Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 31 findings · 2 reviews · Dementia and Cognitive Improvement

No studies found 2 · 6.5%GRADE not reported 0 · 0%Very low 2 · 6.5%Low 13 · 41.9%Moderate 6 · 19.4%High 8 · 25.8%

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Cognitive function · people with dementia
2 findings from 1 review

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Dropout due to lack of efficacy of trial medication or deterioration in overall medical condition · people with dementia

Discontinuing cholinesterase inhibitor showed no clear difference in dropout due to lack of efficacy of trial medication or deterioration… compared with continued cholinesterase inhibitor (low certainty).

1 finding from 1 review

Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor

Change in NPI · people with dementia
2 findings from 1 review

Intervention not reported

Clinical Global (CIBIC+) · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    10 studies · 2797 participants
    High

Intervention not reported

Clinical Global: (CIBIC+) · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 757 participants
    Moderate

Intervention not reported

Cognitive function: ADAS‐Cog 70‐point scale · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 569 participants
    Moderate

Intervention not reported

Performance on ADL (NOSGER self care subscale) Subscale 5 points · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 542 participants
    Low

Intervention not reported

Behaviour: NOSGER disturbing behaviour subscale Subscale 5 points · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 542 participants
    Low

Intervention not reported

Binary outcomes · vascular dementia, mild‐to‐moderate severity

The review found no eligible studies for this question.

1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Intervention not reported

All‐cause discontinuation · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 900 participants
    Low

Intervention not reported

Number suffering at least one adverse event · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    29 studies · 8033 participants
    High

Intervention not reported

Number suffering at least one serious adverse event · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 900 participants
    Low