Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 6 reviews · Oral Health

No studies found 0 · 0%GRADE not reported 8 · 88.9%Very low 0 · 0%Low 1 · 11.1%Moderate 0 · 0%High 0 · 0%

Cranberry extract or cranberry flavonoid fractions vs No extract or vehicle control; other antimicrobial agents

Biofilm morphology or biomass · Streptococcus mutans (in vitro cultures and biofilms)

No meta-analysis was conducted; four included studies reported disrupted biofilm structure or reduced biomass with cranberry extract or fractions.

1 finding from 1 review

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Rate of orthodontic tooth movement (OTM) during space closure stage (en masse, mm/month) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

Light vibrational forces (LVF) showed no clear difference in rate of orthodontic tooth movement (OTM) during space closure stage… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Body‐mass index (BMI) · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Body mass index: Z score -0.15 (95% CI -0.19 to -0.11), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Dietary counselling tailored to a Stage of Change (Transtheoretical Model) to increase fruit and vegetable intake (two counselling sessions) vs usual care

Body‐mass index (BMI) · Edentulous patients aged 45 to 80 years attending dental-student teaching clinics for replacement dentures, Newcastle Dental Hospital, UK
1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Pain on palpation of right masseter muscle (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in pain on palpation of right masseter muscle (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Topical methyl salicylate (Theraflex-TMJ) vs placebo

Spontaneous masseter muscle pain (numerical graph rating scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical methyl salicylate (Theraflex-TMJ) led to lower spontaneous masseter muscle pain (numerical graph rating scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Pain on palpation of left masseter muscle (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in pain on palpation of left masseter muscle (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review