Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 6 · 85.7%Moderate 1 · 14.3%High 0 · 0%

Change in frequency of vaso‐occlusive painful crises (as measured by pain diary days with significant pain) · people with sickle cell disease

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 104 participants
Moderate

HRQoL score (Child‐reported PedsQL generic scale) at 1 week · people with sickle cell disease

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 202 participants
Low

HRQoL score (Child‐reported PedsQL multidimensional fatigue scale) at 1 week · people with sickle cell disease

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 202 participants
Low

HRQoL score (Child‐reported PedsQL sickle cell disease module) at 1 week · people with sickle cell disease

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 202 participants
Low

Length of hospital stay · people with sickle cell disease

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 104 participants
Low

Hypotension · people with sickle cell disease

Intravenous magnesium sulphate showed no clear difference in adverse effects: hypotension compared with placebo (low certainty).

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
RR 2.57 [0.5, 13.08]
2 studies · 306 participants
Low

Adverse effects: warmth at infusion site · people with sickle cell disease

Intravenous magnesium sulphate may leads to higher adverse effects: warmth at infusion site compared with placebo (low certainty).

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
RR 13.26 [3.23, 54.4]
1 study · 202 participants
Low