Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 1 reviews · Neuromuscular

No studies found 2 · 16.7%GRADE not reported 0 · 0%Very low 4 · 33.3%Low 2 · 16.7%Moderate 3 · 25%High 1 · 8.3%

Intervention not reported

Cramp frequency (percentage change from baseline at 4 weeks) · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

The intervention showed no clear difference in cramp frequency (percentage change from baseline at 4 weeks) (moderate certainty).

1 finding from 1 review

Intervention not reported

Cramp frequency (mean number of cramps per week on treatment at 4 weeks) · pregnant women with leg cramps
1 finding from 1 review

Intervention not reported

Cramp intensity (moderate or worse at 4 weeks) · pregnant women with leg cramps

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cramp duration (≥ 1 minute at 4 weeks) · pregnant women with leg cramps

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cramp frequency (responder analysis: 25% or better reduction at 4 weeks) · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

The intervention showed no clear difference in cramp frequency (responder analysis: 25% or better reduction at 4… (high certainty).

1 finding from 1 review

Intervention not reported

Cramp frequency (mean number of cramps per week on treatment at 4 weeks) · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

The intervention showed no clear difference in cramp frequency (mean number of cramps per week on treatment at 4… (moderate certainty).

1 finding from 1 review

Intervention not reported

Cramp intensity (moderate or worse at 4 weeks) · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

The intervention showed no clear difference in cramp intensity (moderate or worse at 4 weeks) (moderate certainty).

1 finding from 1 review

Intervention not reported

Cramp duration (≥ 1 minute at 4 weeks) · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

The intervention showed no clear difference in cramp duration (≥ 1 minute at 4 weeks) (low certainty).

1 finding from 1 review

Intervention not reported

Major adverse events · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

It is very uncertain whether the intervention changes major adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Minor adverse events · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

The intervention showed no clear difference in minor adverse events (low certainty).

1 finding from 1 review

Intervention not reported

Cramp frequency (percentage change from baseline at 4 weeks) · pregnant women with leg cramps
1 finding from 1 review

Intervention not reported

Cramp frequency (responder analysis: 25% or better reduction at 4 weeks) · pregnant women with leg cramps
1 finding from 1 review