Findings

What do systematic reviews say?

16 questions · 17 findings · 2 reviews · Sexually Transmitted Infections

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No studies found 3 · 17.6%GRADE not reported 1 · 5.9%Very low 4 · 23.5%Low 8 · 47.1%Moderate 1 · 5.9%High 0 · 0%

Macrolides vs other antibiotics

Clinical cure: syndromic approach · sexually active adults

Macrolides showed no clear difference in clinical cure: syndromic approach compared with any other antibiotic (low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 1.09 [0.97, 1.21]
2 studies · 340 participants
Low

Macrolides vs other antibiotics

Clinical cure: aetiological approach · sexually active adults

Macrolides showed no clear difference in clinical cure: aetiological approach compared with any other antibiotic (low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 1.06 [0.98, 1.15]
5 studies · 348 participants
Low

Macrolides vs other antibiotics

Clinical improvement: syndromic approach · sexually active adults

It is very uncertain whether macrolides changes clinical improvement: syndromic approach compared with any other antibiotic (very low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 0.89 [0.52, 1.52]
2 studies · 340 participants
Very low

Macrolides vs other antibiotics

Clinical improvement: aetiological approach · sexually active adults

Macrolides showed no clear difference in clinical improvement: aetiological approach compared with any other antibiotic (low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 0.8 [0.42, 1.51]
3 studies · 187 participants
Low

Macrolides vs other antibiotics

Microbiological cure · sexually active adults

Macrolides showed no clear difference in microbiological cure compared with any other antibiotic (low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 0.93 [0.74, 1.16]
1 study · 45 participants
Low

Macrolides vs other antibiotics

Minor adverse events · sexually active adults

It is very uncertain whether macrolides changes minor adverse events compared with any other antibiotic (very low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 1.34 [0.24, 7.51]
3 studies · 412 participants
Very low

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

It is very uncertain whether regimens containing macrolides (azithromycin) changes clinical cure according to criteria established by study authors… compared with regimens containing tetracycline (doxycycline) (very low certainty).

2 findings from 1 review

Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
RR 1.18 [0.89, 1.55]
Studies not reported
Very low
Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
RR 1.35 [1.1, 1.67]
Studies not reported
Moderate

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Clinical cure according to criteria established by study authors Severe PID · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in clinical cure according to criteria established by study authors… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review

Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
RR 1 [0.96, 1.05]
Studies not reported
Low

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review

Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
RR 0.71 [0.38, 1.34]
Studies not reported
Low

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Microbiological clearance · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in microbiological clearance compared with regimens containing tetracycline (doxycycline); GRADE not reported.

1 finding from 1 review

Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
RR 1.02 [0.98, 1.06]
Studies not reported
GRADE not reported

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Laparoscopic evidence of resolution of PID based on physician opinion · women with PID

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Length of stay · women with PID

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Fertility outcome · women with PID

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Erythromycin vs any other macrolide

Clinical cure: syndromic approach · sexually active adults

Macrolide (erythromycin) showed no clear difference in clinical cure: syndromic approach compared with any other macrolide (low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 1 [0.91, 1.1]
2 studies · 269 participants
Low

Erythromycin vs any other macrolide

Clinical cure: aetiological approach · sexually active adults

Macrolide (erythromycin) showed no clear difference in clinical cure: aetiological approach compared with any other macrolide (low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 1.04 [0.93, 1.16]
2 studies · 211 participants
Low

Erythromycin vs any other macrolide

Minor adverse events · sexually active adults

It is very uncertain whether macrolide (erythromycin) changes minor adverse events compared with any other macrolide (very low certainty).

1 finding from 1 review

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
RR 1.14 [0.63, 2.06]
1 study · 101 participants
Very low