Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

280 questions · 282 findings · 22 reviews · Musculoskeletal

No studies found 87 · 30.9%GRADE not reported 5 · 1.8%Very low 43 · 15.2%Low 94 · 33.3%Moderate 35 · 12.4%High 18 · 6.4%

Any cold therapy vs no cold therapy following total knee replacement

Adverse events Adverse events included discomfort, local skin reactions, superficial infections, cold induced injuries and thrombolytic events · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes total adverse eventsAdverse events included discomfort, local skin… compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Balneotherapy vs drug treatment

Improvement Global improvement on 5‐point scale (very good/good/fair/poor/very poor) · patients with rheumatoid arthritis

It is very uncertain whether balneotherapy changes improvement Global improvement on 5‐point scale (very… compared with drug treatment (very low certainty).

1 finding from 1 review

Balneotherapy vs placebo

Improvement Yes/no based on 5 outcome measures (> 30% reduction in number of swollen joints, > 30% reduction in number of tender joints, > 20% improvement in patient VAS for severity of pain and > 20% improvement in physician VAS) · patients with rheumatoid arthritis

It is very uncertain whether balneotherapy changes improvement Yes/no based on 5 outcome measures (> 30% reduction in… compared with placebo (very low certainty).

1 finding from 1 review