Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 92 findings · 23 reviews · Neuromuscular

No studies found 27 · 29.3%GRADE not reported 14 · 15.2%Very low 7 · 7.6%Low 17 · 18.5%Moderate 23 · 25%High 4 · 4.3%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Methotrexate vs placebo

Change in timed walk at 6 months (%) e.g. 10‐metre or 6‐minute walk test at 6 months ‐ not measured · people with inclusion body myositis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

1 finding from 1 review

Methotrexate vs placebo

Change in muscle mass at 6 months (%) ‐ not measured · people with inclusion body myositis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Change in handgrip strength at 6 months (%) ‐ not measured · people with inclusion body myositis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Significant adverse events · people with inclusion body myositis

Methotrexate probably leads to higher significant adverse events compared with placebo (moderate certainty).

1 finding from 1 review