Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

198 questions · 199 findings · 22 reviews · Musculoskeletal

No studies found 61 · 30.7%GRADE not reported 3 · 1.5%Very low 22 · 11.1%Low 57 · 28.6%Moderate 48 · 24.1%High 8 · 4%

Methotrexate vs placebo

Treatment responsea · children and young people with JIA

Methotrexate may leads to higher treatment responsea(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review