It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 0.93 [0.43, 2]
1 study · 35 participants
Very low

IM injection vs IA injection

Improvement in lower limb perfusion: number of participants with improved TcO₂ reading · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 1.22 [0.86, 1.72]
2 studies · 62 participants
Very low

BM‐MNCs vs mPBSCs

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

BM‐MNCs showed no clear difference in improvement in lower limb perfusion: number of participants with… compared with mPBSCs (low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 1 [0.71, 1.4]
1 study · 104 participants
Low

BM‐MNCs vs mPBSCs

Improvement in lower limb perfusion: TcO₂ reading in mmHg · people with critical limb ischaemia

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Low

Exercise vs no treatment

Intensity of disease signs and symptoms1 · people with non‐ulcerated chronic venous insufficiency

It is very uncertain whether physical exercise changes intensity of disease signs and symptoms: VCSS Scale: 0 to 30 (lower… compared with no treatment (very low certainty).

1 finding from 1 review

Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 49 participants
Very low

Exercise vs no treatment

QoL · people with non‐ulcerated chronic venous insufficiency

It is very uncertain whether physical exercise changes quality of life VEINES‐QOL/SF‐36/CIVIQ‐20 (lower is better) compared with no treatment (very low certainty).

1 finding from 1 review

Physical exercise for the treatment of non‐ulcerated chronic venous insufficiency 2023 · Cochrane Headline outcomes only
MD 4.6
2 studies · 61 participants
Very low

Balneotherapy vs no treatment

Disease severity signs and symptoms score · people with chronic venous insufficiency

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 671 participants
Moderate

Balneotherapy vs dryland exercise

Oedema · people with chronic venous insufficiency

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Low

Balneotherapy vs no treatment

Health‐related quality of life –CIVIQ2 Scale: 20–100 · people with chronic venous insufficiency

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 153 participants
Very low

Balneotherapy vs no treatment

Pain (VAS, scale 0–10, lower is better) · people with chronic venous insufficiency

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 354 participants
Low

Balneotherapy vs no treatment

Oedema(leg circumference in cm, lower is better) · people with chronic venous insufficiency

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 369 participants
Very low

Balneotherapy vs no treatment

Skin pigmentation changes · people with chronic venous insufficiency

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Berotralstat vs placebo or active control

Quality of lifeAngioedema Quality of Life scale (lower score is better)(during · children or adults with Types I or II HAE

1 finding from 1 review

Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 130 participants
Moderate

Berotralstat vs placebo or active control

Disability standardised mean difference (lower is better) (during · children or adults with Types I or II HAE

1 finding from 1 review

Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 50 participants
Low

C1 esterase inhibitor vs placebo or active control

Improvement in quality of life: the difference in quality of life scores for participants surveyed before and after treatment · children or adults with Types I or II HAE

1 finding from 1 review

Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Low

Plasma‐derived C1 esterase inhibitor vs placebo or active control

Quality of lifeAngioedema Quality of Life scale (lower score is better)(during · children or adults with Types I or II HAE

1 finding from 1 review

Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Low