Laxation response: risk of spontaneous rescue‐free bowel movements in the short terma · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
Methylnaltrexone lower dose showed no clear difference in laxation response: risk of spontaneous rescue‐free bowel… compared with higher dose (low certainty).
1 finding from 1 review
Laxation response: risk of spontaneous rescue‐free bowel movements in the medium termb · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
It is very uncertain whether methylnaltrexone lower dose changes laxation response: risk of spontaneous rescue‐free bowel… compared with higher dose (very low certainty).
1 finding from 1 review
Laxation response: patient assessment of change in bowel status at the end of trial · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
Methylnaltrexone lower dose showed no clear difference in laxation response: patient assessment of change in bowel statusgat… compared with higher dose (low certainty).
1 finding from 1 review
Symptoms of opioid withdrawal in the medium term · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
Methylnaltrexone lower dose showed no clear difference in symptoms of opioid withdrawal in the medium term compared with higher dose (low certainty).
1 finding from 1 review
Serious adverse events · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
Methylnaltrexone lower dose showed no clear difference in adverse events compared with higher dose (low certainty).
1 finding from 1 review
Adverse events NRS (scale from 0 to 10; lower score = less toxicity) · adults aged 18 years and older receiving palliative care
1 finding from 1 review
AEs · chronic pain (excluding headache) in adults
It is very uncertain whether CBT changes adverse events (number of people with adverse events) (Lower events… compared with TAU (post‐treatment) (very low certainty).
Painiv, SD units(lower scores indicate less pain) · adults with advanced illness and their unpaid caregivers/families
1 finding from 1 review
Intervention not reported
Disability Post‐treatment Lower scores indicate lower levels of disability · children or adolescents with mixed chronic pain conditions
1 finding from 1 review
Intervention not reported
Depression Post‐treatment Lower scores indicate lower levels of depression · children or adolescents with mixed chronic pain conditions
1 finding from 1 review
Intervention not reported
Anxiety Post‐treatment Lower scores indicate lower levels of anxiety · children or adolescents with mixed chronic pain conditions
1 finding from 1 review
Intervention not reported
Disability Post‐treatment Lower scores indicate lower levels of disability · children or adolescents with headaches
1 finding from 1 review
Intervention not reported
Depression Post‐treatment Lower scores indicate lower levels of depression · children or adolescents with headaches
1 finding from 1 review
Intervention not reported
Anxiety Post‐treatment Lower scores indicate lower levels of anxiety · children or adolescents with headaches
1 finding from 1 review
Intervention not reported
Pain intensity Post‐treatment Lower scores indicate lower levels of pain intensity · children or adolescents with mixed chronic pain conditions
1 finding from 1 review
Migraine frequency Number of attacks · adults with migraine
1 finding from 1 review
Migraine intensityc Lower numbers = lower migraine intensity · adults with migraine
1 finding from 1 review
Moodd Lower numbers = lower reported depression, anxiety and distress symptoms · adults with migraine
1 finding from 1 review
Migraine‐related disabilitye Lower numbers = lower reported migraine‐related disability · adults with migraine
1 finding from 1 review