Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

91 questions · 107 findings · 12 reviews · Vascular

No studies found 25 · 23.4%GRADE not reported 4 · 3.7%Very low 13 · 12.1%Low 34 · 31.8%Moderate 24 · 22.4%High 7 · 6.5%

Low molecular weight heparin vs unfractionated heparin

Success rate of replantation1 (analysed by participant) · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes success rate of replantation1 (analysed by participant, compared with unfractionated heparin (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Success rate of replantation1 (analysed by digit, · patients undergoing digital replantation after traumatic amputation

Low molecular weight heparin showed no clear difference in success rate of replantation1 (analysed by digit, compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Incidence of compromised microcirculation requiring invasive intervention (re‐exploration) (analysed by digit, · patients undergoing digital replantation after traumatic amputation

The review found no eligible studies for this question.

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Incidence of compromised microcirculation requiring invasive intervention (incision) (analysed by participant/digit, · patients undergoing digital replantation after traumatic amputation

The review found no eligible studies for this question.

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Microvascular insufficiency due to vessel occlusion ‐ arterial occlusion (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes microvascular insufficiency due to vessel occlusion ‐ arterial… compared with unfractionated heparin (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Microvascular insufficiency due to vessel occlusion ‐ venous occlusion (analysed by participant, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes microvascular insufficiency due to vessel occlusion ‐ venous… compared with unfractionated heparin (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Complication and adverse reactions ‐ wound bleeding (analysed by participant, · patients undergoing digital replantation after traumatic amputation

Low molecular weight heparin showed no clear difference in complication and adverse reactions ‐ wound bleeding (analysed by… compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Deep vein thrombosis · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin probably leads to lower deep venous thrombosis compared with no prophylaxis or placebo (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Pulmonary embolism · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in pulmonary embolism compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Symptomatic venous thromboembolism · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin may leads to lower symptomatic venous thromboembolism compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Mortality due to other causes · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in mortality due to other causes compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Adverse outcomes · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in adverse outcomes compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Incidence of compromised microcirculation requiring invasive intervention (re‐exploration) (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes incidence of compromised microcirculation requiring invasive… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Incidence of compromised microcirculation requiring invasive intervention (incision) (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes incidence of compromised microcirculation requiring invasive… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Microvascular insufficiency due to vessel occlusion ‐ arterial occlusion (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes microvascular insufficiency due to vessel occlusion ‐ arterial… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Microvascular insufficiency due to vessel occlusion ‐ venous occlusion (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes microvascular insufficiency due to vessel occlusion ‐ venous… compared with no LMWH (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs no LMWH

Success rate of replantation1 (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin (LMWH) changes success rate of replantation1 (analysed by digit, compared with no LMWH (very low certainty).

1 finding from 1 review