Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

237 questions · 238 findings · 41 reviews · Musculoskeletal

No studies found 43 · 18.1%GRADE not reported 7 · 2.9%Very low 48 · 20.2%Low 89 · 37.4%Moderate 39 · 16.4%High 12 · 5%

Low‐dose colchicine vs placebo

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

Low‐dose colchicine may leads to higher participant global assessment of treatment success: proportion with… compared with placebo (low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Global assessment of treatment success · acute gout

Low‐dose colchicine showed no clear difference in participant global assessment of treatment success: Completely… compared with NSAIDs (low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Reduction of inflammation ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Function of target joint ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Number of participants reporting an adverse event · acute gout

Low‐dose colchicine showed no clear difference in total number of participants reporting adverse events compared with NSAIDs (low certainty).

1 finding from 1 review

Low‐dose colchicine vs placebo

Reduction of inflammation ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Low‐dose colchicine vs placebo

Function of target joint ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Low‐dose colchicine vs placebo

Total adverse events · acute gout

Low‐dose colchicine showed no clear difference in total adverse events compared with placebo (low certainty).

1 finding from 1 review