What do systematic reviews say?

Long‐term GnRH agonist therapy vs no additional therapy

It is very uncertain whether long‐term GnRH agonist therapy changes live birth rate compared with no additional therapy (very low certainty).

• Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with… 2019 · Cochrane Headline outcomes only
  RR 0.48 [0.26, 0.87]
  1 study · 147 participants
  Very low

Long‐term GnRH agonist therapy vs no additional therapy

It is very uncertain whether long‐term GnRH agonist therapy changes complication rate compared with no additional therapy (very low certainty).

• Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with… 2019 · Cochrane Headline outcomes only
  Peto OR 1.23 [0.37, 4.14]
  3 studies · 318 participants
  Very low

Long‐term GnRH agonist therapy vs no additional therapy

It is very uncertain whether long‐term GnRH agonist therapy changes clinical pregnancy rate compared with no additional therapy (very low certainty).

• Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with… 2019 · Cochrane Headline outcomes only
  RR 1.13 [0.91, 1.41]
  6 studies · 552 participants
  Very low

Long‐term GnRH agonist therapy vs no additional therapy

It is very uncertain whether long‐term GnRH agonist therapy changes multiple pregnancy rate compared with no additional therapy (very low certainty).

• Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with… 2019 · Cochrane Headline outcomes only
  Peto OR 0.14 [0.04, 0.56]
  2 studies · 208 participants
  Very low

Long‐term GnRH agonist therapy vs no additional therapy

It is very uncertain whether long‐term GnRH agonist therapy changes miscarriage rate compared with no additional therapy (very low certainty).

• Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with… 2019 · Cochrane Headline outcomes only
  Peto OR 0.45 [0.1, 2]
  2 studies · 208 participants
  Very low

Long‐term GnRH agonist therapy vs no additional therapy

• Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 385 participants
  Very low

Long‐term GnRH agonist therapy vs no additional therapy

• Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 267 participants
  Very low