Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Neonatal · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 100%High 0 · 0%

Intervention not reported

Mortality during hospital stay · neonates requiring intubation and ventilation

The intervention showed no clear difference in mortality during hospital stay (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
RR 0.79 [0.4, 1.56]
3 studies · 122 participants
Moderate

Intervention not reported

Length of NICU stay (days) · neonates requiring intubation and ventilation

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
5.4 [0.4, 10.5]
2 studies · 89 participants
Moderate

Intervention not reported

PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) · neonates requiring intubation and ventilation

The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 43 participants
Moderate

Intervention not reported

Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation

The intervention showed no clear difference in poor neurological outcome by 28 days' postnatal age (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
RR 1.34 [0.5, 3.56]
1 study · 43 participants
Moderate

Intervention not reported

The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
MD 1
1 study · 46 participants
Moderate

Intervention not reported

Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation

The intervention probably leads to higher poor neurological outcome by 28 days' postnatal age (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
RR 7.64 [1.02, 57.21]
1 study · 46 participants
Moderate