Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

Intranasal beta‐estradiol vs placebo

Change in frequency of hot flushes from baseline to end of study · women with hot flushes

Intranasal beta‐estradiol showed no clear difference in frequency of hot flushes Change from baseline Intranasal… compared with placebo (moderate certainty).

1 finding from 1 review

Bioidentical hormones for women with vasomotor symptoms 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 458 participants
Moderate

Intranasal beta‐estradiol vs placebo

Adverse effects Intranasal beta‐estradiol 0.021 mg/day, 0.029 mg/day or 0.040 mg/day · women with hot flushes

Intranasal beta‐estradiol probably leads to higher adverse effects Intranasal beta‐estradiol 0.021 mg/day, 0.029 mg/day… compared with placebo (moderate certainty).

1 finding from 1 review

Bioidentical hormones for women with vasomotor symptoms 2016 · Cochrane Headline outcomes only
OR 1.96 [1.26, 3.03]
1 study · 458 participants
Moderate