Intranasal beta‐estradiol vs placebo: Change in frequency of hot flushes from baseline to end of study
Intranasal beta‐estradiol showed no clear difference in frequency of hot flushes Change from baseline Intranasal… compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Intranasal beta‐estradiol vs placebo Frequency of hot flushes Change from baseline Intranasal beta‐estradiol 0.021 mg/day, 0.029 mg/day or 0.040 mg/day · women with hot flushes Intranasal beta‐estradiol showed no clear difference in frequency of hot flushes Change from baseline Intranasal… compared with placebo (moderate certainty). Bioidentical hormones for women with vasomotor symptoms (2016) · Cochrane Headline outcomes only | no estimate extracted | 1 study · 458 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Bioidentical hormones for women with vasomotor symptoms 2016 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.