Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

141 questions · 144 findings · 9 reviews · HIV/AIDS

No studies found 1 · 0.7%GRADE not reported 5 · 3.5%Very low 27 · 18.8%Low 48 · 33.3%Moderate 54 · 37.5%High 9 · 6.3%

Structural and community‐level interventions for increasing condom use vs usual care

HIV incidence (observational studies) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HIV incidence (person/years) compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HIV prevalence · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HIV prevalence compared with standard care (low certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Herpes Simplex Virus 2 (HSV‐2) incidence (person/years) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in herpes Simplex Virus 2 (HSV‐2) incidence (person/years) compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HSV‐2 prevalence · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HSV‐2 prevalence compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Two or more sexual partners in last year · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in two or more sexual partners in last year compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Use of birth control methods (condom use at last sex) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use probably leads to higher use of condom during last sexual intercourse compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Knowledge: condom can prevent STIs · low and high‐risk populations

Structural and community‐level interventions for increasing condom use probably leads to higher knowledge: condom can prevent STIs compared with standard care (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1week) (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower infant Mortality at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks leads to lower HIV Transmission or Death at 9 months among those whose HIV… compared with sdNVP plus ZDV (1 week) (high certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 24 months among those uninfected at birth compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infant Mortality at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks showed no clear difference in infant Mortality at 24 months among those uninfected at birth compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower HIV Transmission or Death at 24 months among those uninfected at birth compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP plus ZDV regimen administered to infants for 14 weeks changes infants with any Severe Adverse Events compared with sdNVP plus ZDV (1 week) (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP plus ZDV regimen administered to infants for 14 weeks changes infants with Probably Related Severe Adverse Events compared with sdNVP plus ZDV (1 week) (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in HIV Transmission at 9 months among those whose HIV diagnostic… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in infant Mortality at 9 months among those whose HIV diagnostic… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

HIV Transmission at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in HIV Transmission at 24 months among those uninfected at birth compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 14 weeks showed no clear difference in infant Mortality at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1week) (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in HIV Transmission or Death at 9 months among those whose HIV… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review