Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,025 questions · 1,043 findings · 32 reviews · Skin · Headline outcomes only

No studies found 390 · 37.4%GRADE not reported 40 · 3.8%Very low 181 · 17.4%Low 183 · 17.5%Moderate 196 · 18.8%High 53 · 5.1%

Clobetasol propionate cream vs prednisone

Disease control (healing of skin lesions) at day 21 · bullous pemphigoid

Clobetasol propionate cream probably leads to higher disease control (healing of skin lesions) at day 21 compared with oral prednisone (moderate certainty).

1 finding from 1 review

Doxycycline vs prednisolone

Treatment‐related mortality at 1 year (mITT) · bullous pemphigoid

Doxycycline probably leads to lower treatment‐related mortality at 1 year (mITT) compared with prednisolone (moderate certainty).

1 finding from 1 review

Doxycycline vs prednisolone

Quality of life (DLQI) adjusted for baseline DLQI, disease severity, age, Karnovsky score, baseline versus week 52. A lower score is more favourable. · bullous pemphigoid
1 finding from 1 review

Doxycycline vs prednisolone

Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data) · bullous pemphigoid

Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty).

1 finding from 1 review

Nicotinamide plus tetracycline vs prednisone

Disease control: complete response at 8 weeks: excluding dropouts · bullous pemphigoid

It is very uncertain whether nicotinamide plus tetracycline changes disease control: complete response at 8 weeks: excluding dropouts compared with prednisone (very low certainty).

1 finding from 1 review