Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

502 questions · 519 findings · 57 reviews · Hepato-Biliary · Headline outcomes only

No studies found 131 · 25.2%GRADE not reported 11 · 2.1%Very low 302 · 58.2%Low 46 · 8.9%Moderate 27 · 5.2%High 2 · 0.4%

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ interferon‐beta versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐beta versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ MTH‐68/B vaccine versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ MTH‐68/B vaccine versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Adverse events (proportion) ‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes adverse events (proportion) ‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Adverse events (number) ‐ interferon‐beta versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes adverse events (proportion) ‐ interferon‐beta versus no intervention compared with no intervention or control intervention (control) (very low certainty).

2 findings from 1 review

Intervention vs no intervention or control intervention (control)

Serious adverse events (number) ‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha · people with acute hepatitis C infection

It is very uncertain whether intervention changes serious adverse events (proportion) ‐ pegylated interferon‐alpha… compared with no intervention or control intervention (control) (very low certainty).

2 findings from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ pegylated interferon‐alpha plus ribavirin… compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs control

Selective bowel decontamination versus inactive control · people undergoing liver transplantation

It is very uncertain whether intervention changes selective bowel decontamination versus inactive control compared with control (very low certainty).

2 findings from 1 review

Intervention vs control

Granulocyte‐colony stimulating factor (G‐CSF) versus placebo · people undergoing liver transplantation

It is very uncertain whether intervention changes granulocyte‐colony stimulating factor (G‐CSF) versus placebo compared with control (very low certainty).

2 findings from 1 review

Intervention vs control

Selective bowel decontamination versus prebiotics with probiotics · people undergoing liver transplantation
2 findings from 1 review

Intervention vs control

Selective bowel decontamination versus prebiotics · people undergoing liver transplantation
2 findings from 1 review

Intervention vs control

Prebiotics with probiotics versus prebiotics · people undergoing liver transplantation
2 findings from 1 review