Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 8 · 53.3%Low 1 · 6.7%Moderate 2 · 13.3%High 4 · 26.7%

Intensive insulin therapy vs conventional insulin therapy

Occurrence of CIP/CIM ‐ in the total population randomised · critically ill patients

Intensive insulin therapy may leads to lower occurrence of CIP/CIM ‐ in total population randomised compared with conventional insulin therapy (low certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Occurrence of CIP/CIM ‐ in screened population · critically ill patients

Intensive insulin therapy probably leads to lower occurrence of CIP/CIM ‐ in screened population compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 30 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 30 days after ICU admission, in total population randomised compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 180 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 180 days after ICU admission, in total population… compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Serious adverse events, ‐ in total population randomised ‐ hypoglycaemia · critically ill patients

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Transplant or graft survival · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes transplant or graft survival compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Delayed graft function · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes delayed graft function Time frame: 1 to 3 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Death: unknown time frame · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes death (any cause) Time frame: 1 to 5 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review