What do systematic reviews say?

Intensive glycaemic control vs conventional glucose control

Intensive glycaemic control may leads to higher adverse events (Hypoglycaemia) compared with standard glycaemic control (low certainty).

• Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia 2017 · Cochrane Headline outcomes only
  RR 2.18 [1.52, 3.14]
  2 studies · 12931 participants
  Low

Intensive glycaemic control vs conventional glucose control

Intensive glycaemic control showed no clear difference in mortality compared with standard glycaemic control (moderate certainty).

• Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia 2017 · Cochrane Headline outcomes only
  RR 1 [0.79, 1.26]
  3 studies · 15888 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

Intensive glycaemic control showed no clear difference in global cognitive function (defined as reduction of at least 3 points… compared with standard glycaemic control (moderate certainty).

• Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia 2017 · Cochrane Headline outcomes only
  RR 0.98 [0.88, 1.08]
  1 study · 11140 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

• Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 2794 participants
  Moderate

Intensive glycaemic control vs conventional glucose control

The review found no eligible studies for this question.

• Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensive glycaemic control vs conventional glucose control

Intensive glycaemic control showed no clear difference in incidence of dementia (defined as dementia according to DSM‐IV) compared with standard glycaemic control (low certainty).

• Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia 2017 · Cochrane Headline outcomes only
  RR 1.27 [0.87, 1.85]
  1 study · 11140 participants
  Low