All‐cause mortality · patients with type 2 diabetes mellitus
Intensive glycaemic control showed no clear difference in mortality compared with standard glycaemic control (moderate certainty).
Cardiovascular mortality · patients with type 2 diabetes mellitus
Intensive glycaemic control showed no clear difference in cardiovascular mortality compared with conventional glycaemic control (moderate certainty).
1 finding from 1 review
Non‐fatal MI · patients with type 2 diabetes mellitus
Intensive glycaemic control probably leads to lower non‐fatal myocardial infarction compared with conventional glycaemic control (moderate certainty).
1 finding from 1 review
Non‐fatal stroke · patients with type 2 diabetes mellitus
Intensive glycaemic control showed no clear difference in non‐fatal stroke compared with conventional glycaemic control (moderate certainty).
1 finding from 1 review
Amputation of lower extremity · patients with type 2 diabetes mellitus
Intensive glycaemic control may leads to lower amputation of lower extremity compared with conventional glycaemic control (low certainty).
1 finding from 1 review
End‐stage renal disease · patients with type 2 diabetes mellitus
Intensive glycaemic control showed no clear difference in end‐stage renal disease compared with conventional glycaemic control (moderate certainty).
1 finding from 1 review
Severe hypoglycaemia · patients with type 2 diabetes mellitus
Intensive glycaemic control leads to higher hypoglycaemia ‐ Severe hypoglycaemia compared with conventional glycaemic control (high certainty).
1 finding from 1 review
Adverse events (Hypoglycaemia) · patients with type 2 diabetes mellitus
Intensive glycaemic control may leads to higher adverse events (Hypoglycaemia) compared with standard glycaemic control (low certainty).
1 finding from 1 review
Global cognitive function (defined as reduction of at least 3 points in MMSE) · patients with type 2 diabetes mellitus
Intensive glycaemic control showed no clear difference in global cognitive function (defined as reduction of at least 3 points… compared with standard glycaemic control (moderate certainty).
1 finding from 1 review
Cognitive function · patients with type 2 diabetes mellitus
1 finding from 1 review
Incidence of MCI · patients with type 2 diabetes mellitus
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Incidence of dementia · patients with type 2 diabetes mellitus
Intensive glycaemic control showed no clear difference in incidence of dementia (defined as dementia according to DSM‐IV) compared with standard glycaemic control (low certainty).
1 finding from 1 review