Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

584 questions · 593 findings · 51 reviews · Airways

No studies found 37 · 6.2%GRADE not reported 40 · 6.7%Very low 44 · 7.4%Low 172 · 29%Moderate 232 · 39.1%High 68 · 11.5%

IV + inhaled beta agonist vs inhaled beta‐agonist

Clinical Failure (children with a severe to moderate overall clinical assessment score at two hours) · patients with acute asthma

IV + inhaled beta agonist probably leads to lower clinical Failure (children with a severe to moderate overall… compared with inhaled beta‐agonist (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Inhaled mannitol vs placebo

Hospitalisations Number of participants experiencing one of more hospitalisations. · people with bronchiectasis

Inhaled mannitol showed no clear difference in hospitalisations Number of participants experiencing one of more… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Inhaled mannitol vs placebo

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · people with bronchiectasis

Inhaled mannitol showed no clear difference in health‐related quality of life measured on the SGRQ Scale from 0 to… compared with placebo (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids vs placebo

Pseudomonas aeruginosa (P aeruginosa) colonisation · people with bronchiectasis

Inhaled corticosteroids showed no clear difference in pseudomonas aeruginosa (P aeruginosa) colonisation compared with placebo (low certainty).

1 finding from 1 review