Findings

What do systematic reviews say?

19 questions · 19 findings · 2 reviews

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No studies found 6 · 31.6%GRADE not reported 0 · 0%Very low 3 · 15.8%Low 10 · 52.6%Moderate 0 · 0%High 0 · 0%

Inhalation before vs during airway clearance techniques

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 63 participants
Low

Inhalation before vs after airway clearance techniques

QoL · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs after airway clearance techniques

Symptom scores · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation before vs after airway clearance techniques

Measures of sputum clearance · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs after airway clearance techniques

LCI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs after airway clearance techniques

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs during airway clearance techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation before vs during airway clearance techniques

QoL · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs during airway clearance techniques

Symptom scores · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 76 participants
Low

Inhalation before vs during airway clearance techniques

Expectorated secretions (sputum wet weight) · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 26 participants
Low

Inhalation before vs during airway clearance techniques

LCI · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

Inhalation before vs during airway clearance techniques

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs after airway clearance techniques

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation before vs after airway clearance techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Dornase alfa vs after airway clearance techniques

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

It is very uncertain whether inhalation of dornase alfa before changes FEV1 (% predicted) change from baseline compared with after airway clearance techniques (very low certainty).

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
MD 0.83
102 participants
Very low

Dornase alfa vs after airway clearance techniques

FVC (% predicted) Change from baseline · adults and children with cystic fibrosis

Inhalation of dornase alfa before showed no clear difference in FVC (% predicted) change from baseline compared with after airway clearance techniques (low certainty).

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
MD 1.06
77 participants
Low

Dornase alfa vs after airway clearance techniques

Measures of QoL and symptom scores · adults and children with cystic fibrosis

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
102 participants
Very low

Dornase alfa vs after airway clearance techniques

FEF25-75 · adults and children with cystic fibrosis

Inhalation of dornase alfa before showed no clear difference in FEF25-75 (% predicted) compared with after airway clearance techniques (low certainty).

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
25 participants
Low

Dornase alfa vs after airway clearance techniques

Adverse effects · adults and children with cystic fibrosis

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
102 participants
Very low