Findings

What do systematic reviews say?

3 questions · 11 findings · 2 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 9 · 81.8%Very low 2 · 18.2%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
18 months
RR 1.75 [0.51, 5.98]
1 study · 18 participants
GRADE not reported
Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
Last contact
RR 1.78 [0.97, 3.28]
1 study · 46 participants
GRADE not reported
Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
3 months
RR 1.94 [1.01, 3.74]
1 study · 45 participants
Very low

Show 2 more findings

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
6 months
RR 1.31 [0.78, 2.22]
1 study · 40 participants
GRADE not reported
Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
12 months
RR 1.65 [0.75, 3.64]
1 study · 24 participants
GRADE not reported

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
Last contact
RR 1.56 [0.77, 3.18]
1 study · 46 participants
GRADE not reported
Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
18 months
RR 1.00 [0.25, 4.00]
1 study · 18 participants
GRADE not reported
Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
6 months
RR 0.95 [0.44, 2.04]
1 study · 40 participants
GRADE not reported

Show 2 more findings

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
12 months
RR 1.20 [0.39, 3.65]
1 study · 24 participants
GRADE not reported
Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
3 months
RR 3.60 [0.87, 14.82]
1 study · 45 participants
Very low

Inactivated-bacteria tablets vs Placebo, fluoride toothpaste, or standard post-filling care (varies by trial)

Improved caries prognosis via restored oral microbiota · Patients after dental filling

Adjuvant postbiotics after dental filling improve caries prognosis by restoring the oral microbiota in one RCT (ungraded).

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
14 days · Clinical; salivary/plaque sampling
One RCT reported that adjuvant postbiotic tablets after dental filling improved caries prognosis by restoring oral microbiota diversity, structure and function and reducing potentially pathogenic bacteria (Liu 2024);…
1 study
GRADE not reported