Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

82 questions · 82 findings · 4 reviews

No studies found 12 · 14.6%GRADE not reported 0 · 0%Very low 25 · 30.5%Low 29 · 35.4%Moderate 16 · 19.5%High 0 · 0%

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Death at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment showed no clear difference in death at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

End‐stage renal disease · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to lower end‐stage kidney disease at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Total remission (complete or partial) at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to higher total remission (complete or partial) at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Complete remission · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to higher complete remission at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Relapse · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment may leads to higher recurrence of disease (relapse) at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (low certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

100% increase in SCr at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to lower 100% increase in serum creatinine at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Adverse events ‐ temporary or permanent discontinuation/hospitalisation at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to higher adverse events: temporary/permanent discontinuation or… compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Adverse events: infection at 3 years · primary membranous nephropathy in adults with nephrotic syndrome

It is very uncertain whether immunosuppressive treatment changes adverse events: infection at 3 years compared with placebo/no treatment/non‐immunosuppressive supportive treatment (very low certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Adverse events: malignancy · primary membranous nephropathy in adults with nephrotic syndrome

It is very uncertain whether immunosuppressive treatment changes adverse events: malignancy at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (very low certainty).

1 finding from 1 review