Findings

What do systematic reviews say?

14 questions · 14 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 2 · 14.3%Very low 3 · 21.4%Low 6 · 42.9%Moderate 3 · 21.4%High 0 · 0%

IPV‐OPV vs IPV

Paralytic wild polio cases at 4 years (Change level from IPV‐OPV to IPV) · infants

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Very low

IPV‐OPV vs OPV

Paralytic wild polio cases (Change in slope at 3 years) · infants

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Very low

IPV‐OPV vs IPV

Persons with protective humoral response (Range of · infants

IPV‐OPV showed no clear difference in persons with protective humoral response (Range of compared with IPV (moderate certainty).

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
RR 1 [0.99, 1.01]
10 studies · 2858 participants
Moderate

IPV‐OPV vs IPV

Neutralising antibodies with 2 IPV doses Geometric mean titres ( · infants

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 363 participants
Moderate

IPV‐OPV vs IPV

Persons with faecal polio excretion after OPV challenge (Range of · infants

It is very uncertain whether IPV‐OPV changes persons with faecal polio excretion after OPV challenge (Range of compared with IPV (very low certainty).

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
RR 0.52 [0.14, 1.97]
2 studies · 822 participants
Very low

IPV‐OPV vs IPV

Vaccination coverage · infants

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

IPV‐OPV vs IPV

Serious adverse events (≥ 1 symptom related to study drug or not) (Range of · infants

IPV‐OPV showed no clear difference in serious adverse events (≥ 1 symptom related to study drug or not)… compared with IPV (low certainty).

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
RR 0.92 [0.6, 1.43]
2 studies · 1063 participants
Low

IPV‐OPV vs OPV

Vaccine‐associated paralytic polio (VAPP) cases (Range of · infants

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Low

IPV‐OPV vs OPV

Persons with protective humoral response (Range of · infants

IPV‐OPV showed no clear difference in persons with protective humoral response (Range of compared with OPV (moderate certainty).

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
RR 1 [0.99, 1.01]
12 studies · 3189 participants
Moderate

IPV‐OPV vs OPV

Neutralising antibodies with 2 IPV doses Geometric mean titres ( · infants

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 795 participants
Low

IPV‐OPV vs OPV

Persons with faecal polio excretion after OPV challenge (Range of · infants

IPV‐OPV showed no clear difference in persons with polio faecal excretion after OPV challenge (Range of compared with OPV (low certainty).

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
RR 2.24 [0.7, 7.12]
2 studies · 916 participants
Low

IPV‐OPV vs OPV

Vaccination coverage · infants

IPV‐OPV showed no clear difference in vaccination coverage ( compared with OPV (low certainty).

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
RR 1.01 [0.96, 1.06]
1 participants
Low

IPV‐OPV vs OPV

Serious adverse events (classified by MedDRA) (Range of · infants

IPV‐OPV showed no clear difference in serious adverse events (classified by MedDRA) (Range of compared with OPV (low certainty).

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
RR 0.88 [0.46, 1.7]
4 studies · 1948 participants
Low

IPV‐OPV vs IPV

Vaccine‐associated paralytic polio (VAPP) cases (Range of · infants

1 finding from 1 review

Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported