Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

660 questions · 679 findings · 99 reviews · Headline outcomes only

No studies found 160 · 23.6%GRADE not reported 17 · 2.5%Very low 199 · 29.3%Low 189 · 27.8%Moderate 97 · 14.3%High 17 · 2.5%

IM injection vs IA injection

Wound/ulcer healing: number of participants with healing ulcer · people with critical limb ischaemia

IM injection showed no clear difference in wound/ulcer healing: number of participants with healing ulcer compared with IA injection (low certainty).

1 finding from 1 review

IM injection vs IA injection

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

IM injection vs IA injection

Improvement in lower limb perfusion: number of participants with improved TcO₂ reading · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

Intervention not reported

NIPS during 1‐2 minutes after IM injection Range of scale 0‐7 A lower score = less pain Lawrence 1993 · neonates with pain associated with intramuscular injection
1 finding from 1 review

Intervention not reported

PIPP during IM injection (term infants) ‐ Infants of non‐diabetic and diabetic mothers Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with pain associated with intramuscular injection
1 finding from 1 review

Slow vs fast subcutaneous heparin injection

Bruise incidence ‐ 48 hours after injection · patients treated with subcutaneous heparin injections

Slow may leads to lower bruise incidence ‐ 48 hours after injection compared with fast subcutaneous heparin injection (low certainty).

2 findings from 1 review

Intervention not reported

Duration of cry (seconds) following IM injection · procedural pain in neonates
1 finding from 1 review

NSAID injection vs glucocorticoid injection

Resolution at 12 to 24 weeks Quinell Grade (range 0 to 4, resolved disease is grade 0) · adults (> 18 years of age) with trigger finger

NSAID injection showed no clear difference in resolution at 12 to 24 weeks Quinell Grade (range 0 to 4, resolved… compared with glucocorticoid injection (low certainty).

1 finding from 1 review