Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 100%High 0 · 0%

Complete remission (CDAI<150 with a decrease in CDAI of at least 100 points from baseline) · induction of remission in Crohn's disease

IL‐10 showed no clear difference in complete remission (CDAI<150 with a decrease in CDAI of at least 100… compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant human interleukin 10 for induction of remission in Crohn's disease 2010 · Cochrane Headline outcomes only
RR 1.43 [0.62, 3.29]
3 studies · 470 participants
Moderate

CDAI <150 at 24 weeks · induction of remission in Crohn's disease

IL‐10 showed no clear difference in clinical remision (CDAI<150) compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant human interleukin 10 for induction of remission in Crohn's disease 2010 · Cochrane Headline outcomes only
RR 1.29 [0.79, 2.11]
3 studies · 470 participants
Moderate

Withdrawls due to adverse events · induction of remission in Crohn's disease

IL‐10 probably leads to higher withdrawls due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant human interleukin 10 for induction of remission in Crohn's disease 2010 · Cochrane Headline outcomes only
RR 13.5 [3.89, 46.79]
2 studies · 228 participants
Moderate