FEV1 · adults with asthma
1 finding from 1 review
Rate of exacerbations requiring systemic corticosteroids · adults with asthma
It is very uncertain whether ICS dose reduction changes exacerbation requiring OCS compared with no change (very low certainty).
2 findings from 1 review
SAEs · adults with asthma
ICS dose reduction showed no clear difference in all‐cause SAEs compared with no change (low certainty).
2 findings from 1 review
Steroid‐related AEs ‐ not reported · adults with asthma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
St. George's Respiratory Scale score (change from baseline) · adults with asthma
1 finding from 1 review
Severe exacerbations requiring hospitalisation over the study period · adults with asthma
ICS dose reduction showed no clear difference in exacerbation requiring hospitalisation compared with no change (low certainty).
1 finding from 1 review
Asthma control · adults with asthma
1 finding from 1 review
Steroid‐related AEs · adults with asthma
It is very uncertain whether ICS dose reduction changes steroid‐related AEs compared with no change (very low certainty).
1 finding from 1 review
Change in AQLQ · adults with asthma
1 finding from 1 review
FEV1 (L) · adults with asthma
1 finding from 1 review
Exacerbation: hospital 17 weeks · adults with asthma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Asthma control (short asthma morbidity score) · adults with asthma
1 finding from 1 review
Intervention not reported
% change from baseline ICS dose Duration of trials: 12 to 24 weeks More reduction is better · adults and adolescents with persistent asthma
1 finding from 1 review
Tardive dyskinesia: No clinically important improvement · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
It is very uncertain whether reduced dose of antipsychotics changes tardive dyskinesia: no clinically important improvement compared with antipsychotic maintenance (very low certainty).
1 finding from 1 review
Tardive dyskinesia: Deterioration of symptoms · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
It is very uncertain whether reduced dose of antipsychotics changes tardive dyskinesia: deterioration of symptoms compared with antipsychotic maintenance (very low certainty).
1 finding from 1 review
General mental state: relapse · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
It is very uncertain whether reduced dose of antipsychotics changes general mental state: relapse compared with antipsychotic maintenance (very low certainty).
1 finding from 1 review
RR 3 [0.16, 57.36]
1 study · 8 participants
Very low
Adverse effect: any ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
1 finding from 1 review
Adverse effect: extrapyramidal symptoms ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
1 finding from 1 review
Leaving the study early · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
It is very uncertain whether reduced dose of antipsychotics changes acceptability of the treatment: leaving the study early compared with antipsychotic maintenance (very low certainty).
1 finding from 1 review
RR 0.33 [0.06, 1.99]
1 study · 8 participants
Very low
Social confidence, social inclusion, social networks, or personalised quality of life ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
1 finding from 1 review