Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 1 reviews

No studies found 3 · 21.4%GRADE not reported 0 · 0%Very low 4 · 28.6%Low 4 · 28.6%Moderate 3 · 21.4%High 0 · 0%

Hypoxia‐inducible factor (HIF) stabilisers vs erythropoiesis‐stimulating agent (ESA)

Nonfatal myocardial infarction Median · people with CKD (including HD and PD)

Hypoxia‐inducible factor (HIF) stabilisers showed no clear difference in nonfatal myocardial infarction Median compared with erythropoiesis‐stimulating agent (ESA) (low certainty).

1 finding from 1 review

Hypoxia‐inducible factor (HIF) stabilisers vs erythropoiesis‐stimulating agent (ESA)

Nonfatal stroke Median · people with CKD (including HD and PD)

Hypoxia‐inducible factor (HIF) stabilisers showed no clear difference in nonfatal stroke Median compared with erythropoiesis‐stimulating agent (ESA) (low certainty).

1 finding from 1 review

Hypoxia‐inducible factor (HIF) stabilisers vs erythropoiesis‐stimulating agent (ESA)

Blood transfusion · people with CKD (including HD and PD)

Hypoxia‐inducible factor (HIF) stabilisers showed no clear difference in proportion of patients requiring blood transfusion Median compared with erythropoiesis‐stimulating agent (ESA) (moderate certainty).

1 finding from 1 review

Hypoxia‐inducible factor (HIF) stabilisers vs erythropoiesis‐stimulating agent (ESA)

Proportion reaching target haemoglobin Median · people with CKD (including HD and PD)

Hypoxia‐inducible factor (HIF) stabilisers showed no clear difference in proportion reaching target haemoglobin Median compared with erythropoiesis‐stimulating agent (ESA) (low certainty).

1 finding from 1 review

Hypoxia‐inducible factor (HIF) stabilisers vs placebo

Proportion reaching target haemoglobin Median · people with CKD (including HD and PD)

Hypoxia‐inducible factor (HIF) stabilisers probably leads to higher proportion reaching target haemoglobin Median compared with placebo (moderate certainty).

1 finding from 1 review

Hypoxia‐inducible factor (HIF) stabilisers vs erythropoiesis‐stimulating agent (ESA)

Cardiovascular mortality · people with CKD (including HD and PD)

Hypoxia‐inducible factor (HIF) stabilisers showed no clear difference in cardiovascular death Median compared with erythropoiesis‐stimulating agent (ESA) (low certainty).

1 finding from 1 review

Hypoxia‐inducible factor (HIF) stabilisers vs erythropoiesis‐stimulating agent (ESA)

Fatigue · people with CKD (including HD and PD)

It is very uncertain whether hypoxia‐inducible factor (HIF) stabilisers changes fatigue Median compared with erythropoiesis‐stimulating agent (ESA) (very low certainty).

1 finding from 1 review