What do systematic reviews say?

Hypothermic machine perfusion vs static cold storage (SCS)

Hypothermic machine perfusion leads to lower DGF compared with static cold storage (high certainty).

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  RR 0.77 [0.67, 0.9]
  14 studies · 2138 participants
  High

Hypothermic machine perfusion vs static cold storage (SCS)

Hypothermic machine perfusion showed no clear difference in treated acute rejection in the first year compared with static cold storage (low certainty).

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  RR 0.66 [0.37, 1.17]
  2 studies · 248 participants
  Low

Hypothermic machine perfusion vs static cold storage (SCS)

Hypothermic machine perfusion leads to lower DGF: DCD group compared with static cold storage (high certainty).

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  RR 0.75 [0.64, 0.87]
  7 studies · 772 participants
  High

Hypothermic machine perfusion vs static cold storage (SCS)

Hypothermic machine perfusion leads to lower DGF: DBD group compared with static cold storage (high certainty).

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  RR 0.78 [0.65, 0.93]
  4 studies · 971 participants
  High

Hypothermic machine perfusion vs static cold storage (SCS)

Hypothermic machine perfusion leads to lower DGF: modern era studies compared with static cold storage (high certainty).

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  RR 0.77 [0.66, 0.91]
  5 studies · 1355 participants
  High

Hypothermic machine perfusion vs static cold storage (SCS)

Hypothermic machine perfusion leads to lower DGF: pre‐2008 studies compared with static cold storage (high certainty).

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  RR 0.78 [0.61, 0.99]
  9 studies · 783 participants
  High

Hypothermic machine perfusion vs static cold storage (SCS)

The review found no eligible studies for this question.

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hypothermic machine perfusion vs static cold storage (SCS)

Hypothermic machine perfusion showed no clear difference in PNF compared with static cold storage (high certainty).

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  RR 0.88 [0.58, 1.33]
  7 studies · 1387 participants
  High

Hypothermic machine perfusion vs static cold storage (SCS)

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 220 participants
  Very low

Hypothermic machine perfusion vs static cold storage (SCS)

Hypothermic machine perfusion showed no clear difference in one year patient survival compared with static cold storage (low certainty).

• Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation 2019 · Cochrane Headline outcomes only
  RR 0.99 [0.95, 1.03]
  3 studies · 920 participants
  Low